PEEP Setting in COVID19-related ARDS
- Conditions
- ARDS Due to Severe Acute Respiratory Syndrome Coronavirus 2
- Registration Number
- NCT05115526
- Lead Sponsor
- Central Hospital, Nancy, France
- Brief Summary
The best way to titrate positive end-expiratory pressure (PEEP) in patients suffering from acute respiratory distress syndrome is still matter of debate. Electrical impedance tomography (EIT) in a non-invasive technique that could guide PEEP setting based on an optimized ventilation homogeneity.
- Detailed Description
COVID-19 related ARDS patients admitted to the ICU in March 2021 requiring mechanical ventilation were enrolled. Patients were monitored by an esophageal catheter and a 32-electrode EIT device. Within 48 hours after the start of mechanical ventilation, different levels of PEEP were applied based upon PEEP/ Fraction of inspired oxygen tables, positive end-expiratory transpulmonary (PL)/ FiO2 table, and EIT. Respiratory mechanics variables were recorded.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 17
- COVID19-related ARDS under invasive mechanical ventilation
- none
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Value of PEEP a single determination, within 24-48 hours after mechanical ventilation initiation different PEEP values obtained through using different methods
- Secondary Outcome Measures
Name Time Method Respiratory mechanics a single determination, within 24-48 hours after mechanical ventilation initiation Respiratory mechanics (plateau pressure, driving pressure, compliance, mechanical power) following different PEEP settings
Trial Locations
- Locations (1)
Service de Réanimation Médicale, Hôpital Central
🇫🇷Nancy, France