A Randomized Open Label Controlled Clinical Study to Compare the Efficacy of Rasanjanadya Aschyotana and Olopatadine 0.1% Eye Drops in the Management of Kaphaja Abhishyanda (Simple Allergic Conjunctivitis)
Trial Snapshot
- Phase
- Phase 2
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 44
- Locations
- 1
- Primary Endpoint
- 1. Change in scoring pattern of sign and symptoms of Kaphaja Abhishyanda (Simple Allergic Conjunctivitis).
Study Overview
Brief Summary
Kaphaja Abhishayanda is characterized by Ushnaabhinanda (Want of warmth), Guruta (heaviness of lids), Akhshishopha (swelling of eyes), Kandu (itching), Updeha (stickiness in eyes), Atisitata (Excessive coldness), Sravamuhurpichila (recurrent excessive slimy discharge from eye); so, on the basis of signs and symptoms Kaphaja Abhishyanda can be correlated with Simple Allergic Conjunctivitis. Simple Allergic Conjunctivitis, is a type-1 immediate hypersensitivity reaction mediated by IgE and subsequent mast cell activation, following exposure of ocular surface to airborne allergens.Ayurveda offers an alternative and holistic approach to manage such conditions using herbal formulations that aim at correcting the doshic imbalance while providing symptomatic relief. Rasanjanadya Aschyotana, an Ayurvedic eye drop formulation comprising ingredients like Rasanjana, Haridra, and Madhu is described in classical texts for Kaphaja Abhishyanda*.*This study is designed to evaluate and compare the therapeutic efficacy of Rasanjanadya Aschyotana with that of Olopatadine 0.1% eye drops (Dual action antihistamine and mast cell stabilizer) in patients suffering from Kaphaja Abhishyanda (Simple Allergic Conjunctivitis). By employing a randomized open-label controlled clinical trial design, this research aims to generate scientific evidence for the effectiveness of Rasanjanadya Aschyotana, potentially establishing it as a viable, natural alternative to modern pharmacotherapy.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Masking
- None
Eligibility Criteria
- Ages
- 16.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Age- 16-60 years
- •Patients with sign and symptoms of Kaphaja Abhishyanda (Simple Allergic Conjunctivitis) will be selected irrespective of Sex, Religion and Profession.
- •Patients those are fit for Aschyotana Karma according to Ayurveda text
- •Patient willing to participate and able to provide signed informed consent.
Exclusion Criteria
- •Age group less than 16 years and more than 60 years.
- •The patient having any systemic illness, like.
- •Diabetes mellitus, Hypertension, Tuberculosis, etc.
- •Patients suffering from other type of Conjunctivitis, Marginal Corneal Ulcer, Dacryocystitis and other ocular manifestations.
- •Patients with alcohol, opioids / drug addiction and using any other systemic drugs which may alter the result of study.
- •Patients having genetic predisposition to allergy.
- •Pregnant and lactating mothers.
Outcomes
Primary Outcomes
1. Change in scoring pattern of sign and symptoms of Kaphaja Abhishyanda (Simple Allergic Conjunctivitis).
Time Frame: 35th day
Secondary Outcomes
No secondary outcomes reported
Investigators
Dr Prerna
Institute for Ayurved Studies and Research SKAU Kurukshetra