isng changes in pulmonary mechanics and gas exchange to better define the optimal pulmonary volume in patients ventilated for acute lung injury
Recruiting
- Conditions
- ARDS10024967respiratory insufficiency
- Registration Number
- NL-OMON32764
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
1. Inclusion criteria
* Mechanically ventilated
* Have lung pathology (either primary or secondary) who fulfil the definition of Acute Lung Injury (ALI) or Acute Respiratory Distress Syndrome (ARDS) -see below
* And their parents agree for them to participate in the study and give given written informed consent
Exclusion Criteria
* Children ventilated for an obstructive lung pathology
* Children with raised intracranial pressure or a head injury
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>* Comparison of pulmonary physiological, circulatory, and ventilatory<br /><br>parameters in each patient, enabling correlation between these parameters:<br /><br>haemodynamic parameters, blood gas analysis including oxygen<br /><br>saturation, PaO2/ FiO2, v CO2, opening pressure, closing pressure,<br /><br>oesophageal pressure, plus during CMV we will also measure dynamic<br /><br>compliance, elastance, respiratory inductance plethysmography and deadspace.<br /><br>* Correlation of PEEP/MAP and the TPP with currently used markers indicating<br /><br>achievement optimal lung volume (pO2, p CO2, dynamic compliance, deadspace).<br /><br>* Comparison of two groups * to compare above parameters between the two<br /><br>groups of primary and secondary ARDS </p><br>
- Secondary Outcome Measures
Name Time Method <p>bloodgasses, hemodynamics</p><br>