Optimising Lung Volume in Children/Tamariki Ventilated for Lung Problems

Not Applicable

Recruiting

• Conditions: Acute lung injury; Acute Respiratory Distress Syndrome (ARDS); Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12610000552088
• Lead Sponsor: Dr Jan Kelly

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-07-09
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Mechanically ventilated.
Lung pathology fulfilling criteria for acute lung injury or acute respiratory distress syndrome.

Exclusion Criteria

Children ventilated for an obstructive lung pathology.
Children with raised intracranial pressure or a head injury.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measurement of the transpulmonary pressure (TPP). TPP calculated from oesophageal pressure measured using a nasogastric or orgastric tube with air filled oesophageal catheter, and lung volume change measured using respiratory inductance plethymography (one thoracic and one abdominal band). Both measurements made by the Bicore II device.[Measurements are made during the stepped PEEP recruitment manoever. Measurements are made at the end of each PEEP / MAP step after stabilisation of oxygenation and TcCO2.];Comparison of the transpulmonary pressure (TPP) with other measures indicating the open lung state (oxygenation, carbon dioxide clearance measured by transcutaneous carbon dioxide, lung compliance during conventional ventilation).[Measurements are made during the stepped PEEP recruitment manoever. Measurements are made at the end of each PEEP / MAP step after stabilisation of oxygenation and TcCO2.]

Secondary Outcome Measures

Name	Time	Method
Comparison of two groups- direct and indirect lung injury during stepped PEEP recruitment over a period of one to three hours.[Measurements are made during the stepped PEEP recruitment manoever. Measurements are made at the end of each PEEP / MAP step after stabilisation of oxygenation and TcCO2.]