Effect of platelet rich fibrin on bone regeneration in combination with xenograft after maxillary sinus augmentation: A histology and gene expression study
- Conditions
- Platelet rich fibrin, maxillary sinus floor augmentation, gene expression, xenograftPneumatization of the maxillary sinus in patients with healthy medical conditions requiring two-staged maxillary sinus augmentation.
- Registration Number
- TCTR20220510011
- Lead Sponsor
- Faculty of Dentistry, Chiang Mai university,
- Brief Summary
The newly formed bone, contact length between groups did not significant difference. the statistically significant difference was found in the mean percentage of residual bone graft among the groups. There was no significant difference in relative gene expression between groups.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 13
1. two-staged maxillary sinus augmentation was required prior to implant placement, 2. Systemically healthy, 3. Residual alveolar bone height of less than 5mm, 4. Age over 18 years.
1. Patients with medical disorders that may impair bone healing, such as uncontrolled diabetes, hypertension, or those taking bisphosphonate or steroid therapy, 2. Smokers, 3. History of maxillary sinusitis, 4.History of reconstructive or previous implant surgery, 5. Being edentulous less than 3 months, 6. Maxillary sinus septum.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method histology, histomorphometry parameters after 6 months of maxillary sinus augmentation area of new bone formation, residual bone graft, contact length between newly formed bone and residual bone graft,gene expression level after 6 months of maxillary sinus augmentation realtime RT-PCR
- Secondary Outcome Measures
Name Time Method linear analysis of radiographic evaluation post-operative 7 days and post-operative 6 months of maxillary sinus augmentation distance between lowest point of alveolar bone to highest point of grafted bone,volumetric analysis of radiographic evaluation post-operative 7 days and post-operative 6 months of maxillary sinus augmentation segmentation technique in CBCT scan