Perioperative Respiratory Support and Postoperative Outcomes: Russian National Epidemiological Study "RuVent-A"
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 1,000
- Primary Endpoint
- Incidence of Postoperative Pulmonary Complications (PPCs)
Study Overview
Brief Summary
This study aims to evaluate the methodology and parameters of perioperative respiratory support (RS) and the frequency of postoperative pulmonary complications (PPCs) in the Russian Federation. The study will analyze respiratory support strategies, equipment availability, and their correlation with PPC outcomes in surgical patients.
Detailed Description
Globally, around 230 million surgical procedures requiring general anesthesia and mechanical ventilation are performed annually. Postoperative pulmonary complications (PPCs) significantly impact clinical outcomes, increasing morbidity and hospitalization duration. Cohort studies have reported a 20-30% risk of PPCs in patients undergoing general anesthesia. Protective ventilation strategies, including low tidal volumes (6-8 mL/kg predicted body weight) and positive end-expiratory pressure (PEEP), have shown to reduce PPCs. However, high tidal volumes (10-15 mL/kg) remain prevalent in routine practice.
The "RuVent-A" study will collect data on respiratory support methodologies, initial ventilation parameters, types of surgical interventions, and associated PPC rates in the Russian Federation. This observational study will analyze patient and equipment data across participating centers without altering routine clinical practices.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients aged ≥18 years undergoing surgical procedures with general anesthesia and respiratory support.
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Incidence of Postoperative Pulmonary Complications (PPCs)
Time Frame: 30 days after surgery
The frequency of postoperative pulmonary complications (PPCs) will be measured, including conditions such as atelectasis, hypoxemia, pneumonia, acute respiratory distress syndrome (ARDS), and bronchospasm. PPCs will be evaluated based on clinical and diagnostic criteria following surgery.
Secondary Outcomes
- Level of end-expiratory pressure during anesthesia(During surgery (intraoperative period).)
- Use of Alveolar Recruitment Maneuvers During Anesthesia(During surgery (intraoperative period).)
- Frequency of Non-Invasive Ventilation and High-Flow Oxygen Therapy Post-Extubation(30 days after surgery)
- Duration of Intraoperative and Postoperative Mechanical Ventilation(Intraoperative and up to 24 hours postoperatively.)
- Incidence of Hypoxemia Post-Surgery(30 days after surgery)
- Level of inspiratory oxygen fraction during anesthesia(During surgery (intraoperative period).)
- Level of tidal volume during anesthesia(During surgery (intraoperative period).)