Use of ΔIVC for Early Diagnosis of AHF in AECOPD

Completed

• Conditions: COPD Exacerbation; Acute Decompensated Heart Failure
• Interventions: Diagnostic Test: calculation of the inferior vena cava collapsibility index

• Registration Number: NCT05327374
• Lead Sponsor: University of Monastir

Brief Summary

Acute Heart failure (AHF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

This association is frequently underestimated with regard to the difficulty of clinical diagnosis.

The investigators expect that the application of the inferior vena cava collapsibility index (ΔIVC)could be useful in this issue.

Detailed Description

Acute heart failure (AHF) is a common cause of COPD exacerbation however its role is very often underestimated. Until now, the use of echocardiography and some invasive hemodynamic exploration techniques such as the Swanganz catheter has been stated as reference. Other noninvasive diagnostic methods have been studied, such as systolic time intervals and Valsalva maneuver, but their application still difficult in patients with COPD exacerbation, especially in emergency department (ED) settings. the study aimed to evaluate the performance of a new diagnostic technique based on the measurement of the ΔIVC for the early identification of AHF in patients presenting to the ED with acute COPD exacerbation.

Study Timeline

• Study Start: 2022-03-01
• Study First Submitted: 2022-03-14
• Study First Submitted QC: 2022-04-06
• Study First Posted: 2022-04-14
• Primary Completion: 2022-11-30
• Study Completion: 2023-01-31
• Status Verified: 2023-05
• Last Update Submitted: 2023-05-13
• Last Update Posted: 2023-05-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 401

Inclusion Criteria

• patient with history of COPD and admitted to the emergency departement for AECOPD

Exclusion Criteria

• impossibility to give consent to participate in the study, non consent patients
• post traumatic dyspnea
• instable hemodynamic or neurological status

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
non AHF-group	calculation of the inferior vena cava collapsibility index	patients with AECOPD without acute heart failure
AHF-group	calculation of the inferior vena cava collapsibility index	patients with AECOPD and acute heart failure

Primary Outcome Measures

Name	Time	Method
the performance of ΔIVC in the diagnosis of acute heart failure	1 day	the accuracy of ΔIVC in the diagnosis of heart failure measured by sensitivity ,specificity, and area under the roc curve

Trial Locations

Locations (3)

Emergency department of fattouma bourguiba university hospital; 🇹🇳 Monastir, Tunisia

CHU Fattouma Bourguiba; 🇹🇳 Monastir, Tunisia

Emergency Departement; 🇹🇳 Monastir, Tunisia