Effects of HIIT in Tolerance to Exercise of Individuals With HF and Coexisting COPD
- Conditions
- Chronic Obstructive Pulmonary DiseaseHeart Failure
- Interventions
- Other: Continuous aerobic trainingOther: High-intensity interval training
- Registration Number
- NCT04350541
- Lead Sponsor
- Universidade Federal de Pernambuco
- Brief Summary
INTRODUCTION: The complexity of the pathophysiology of heterogeneous diseases such as heart failure and obstructive pulmonary disease causes a different approach to these diseases or with a view as much as a better understanding of the same situations, with which the clinical profile of patients who are associated with an association is. It is known that regular physical training promotes progressive improvements in exercise tolerance, in the pulmonary ventilation / perfusion ratio and in respiratory function by strengthening. OBJECTIVE: To compare the effects of high-intensity interval training and continuous aerobic exercise, with peripheral endothelial function, brain natriuretic peptide levels, maximum exercise tolerance, distribution of lung volumes and quality of life of patients with obstructive pulmonary disease associated with heart failure. METHODS: This is a clinical, controlled, randomized and blinded trial. Peripheral endothelial function, tolerance to maximum and submaximal exercise, distribution of lung volumes, quality of life, presence of symptoms of depression and perception of clinical change will be evaluated. EXPECTED RESULTS: Incorporate into the care of these patients, new effective therapeutic approaches, of low cost and with greater technical and scientific evidence.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- SUSPENDED
- Sex
- All
- Target Recruitment
- 40
- Sedentary individuals with Heart Failure of all etiologies;
- Diagnosed moderate and severe chronic obstructive pulmonary disease;
- Clinical stability;
- No change in the medication class within three months before the beginning of the research.
- Unstable angina;
- Myocardial infarction;
- Previous cardiac surgery up to three months before the beginning of the study;
- Hemodynamic instability;
- Orthopedic and neurological diseases;
- Psychological and/or mental impairment.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Continuous training Continuous aerobic training The continuous aerobic training will consist of 10 minutes of warm-up with intensity between 40 and 50% of VO2peak, 20 minutes of conditioning between 60 and 70% of VO2peak and 5 minutes of cooling down between 30 and 40% of VO2peak. Interval training High-intensity interval training Interval training will consist of 10 minutes of warm-up between 40-50% of the peak oxygen consumption (VO2peak), followed by four to six repetitions of three-minute intervals between 80-90% of VO2peak and three minutes between 40-50% VO2peak and finally, five minutes of cooling down between 30-40% of VO2peak.
- Primary Outcome Measures
Name Time Method Peripheral endothelial function 24 weeks Evaluated by the peripheral arterial tonometry using the EndoPat 2000 device
Exercise tolerance 24 weeks Evaluated by the cardiopulmonary exercise test by measuring the maximum oxygen consumption.
- Secondary Outcome Measures
Name Time Method Perception of clinical change 24 weeks Evaluated by the Patient Global Impression of Change Scale which is a one-dimensional measure in which individuals can rate their associated improvement on a 7-item scale ranging from "1 = no changes" to "7 = much better".
Quality of life assessment: Short Form-36 questionnaire 24 weeks Evaluated by the Short Form-36 questionnaire
Distance covered in the six-minute walk test 24 weeks Evaluated by the six-minute walk test
Trial Locations
- Locations (1)
Federal University of Pernambuco
🇧🇷Recife, Pernambuco, Brazil