A New Marker for Early Diagnosis of Pneumoperitoneum-Related Acute Kidney Injury: Insulin-Like Growth Factor-1 (IGF-1)

Not Applicable

Completed

• Conditions: Acute Kidney Injury (Nontraumatic); Pneumoperitoneum
• Interventions: Diagnostic Test: IGF-1

• Registration Number: NCT05612802
• Lead Sponsor: Baskent University

Brief Summary

In our study, to show the effect of pneumoperitoneum on acute kidney injury in patients scheduled for laparoscopic surgery, NGAL and IGF-1 values will be measured before, after and 24 hours after pneumoperitoneum, and these values will be compared. In our study, we aimed to investigate the effect of pneumoperitoneum applied on acute kidney injury in patients who underwent laparoscopic surgery. Creatinine and NGAL have been used successfully in the follow-up of acute kidney injury. Our study investigates whether IGF-1 will be an effective indicator in acute kidney injury by comparing IGF-1 and NGAL values before pneumoperitoneum, after pneumoperitoneum and at the postoperative 24th hour.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-09-06
• Study First Submitted QC: 2022-11-08
• Study First Posted: 2022-11-10
• Study Start: 2023-02-08
• Primary Completion: 2023-03-30
• Study Completion: 2023-05-30
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-03
• Last Update Posted: 2024-01-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• Patients aged 18-70 years of both sexes
• ASA I-III Patients

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Exclusion Criteria

• Obesity,
• Chronic Kidney Disease,
• Chronic Renal Failure,
• Acute Renal Failure,
• Peripheral and ischemic vascular disease,
• Chronic Heart Failure,
• History of anaphylaxis,
• A-V block,
• Creatinine level >1.4,
• Neuromuscular disease,
• Malignant hypertension,
• Pyelonephritis,
• Urinary tract infectio,
• Severe inflammation/possible sepsis,
• Active malignancy,
• Patients with surgery reversion to laparotomy,
• Hemodynamic instability, need for vasopressors,
• Severe bleeding requiring blood transfusion,

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
IGF	IGF-1	Creatinine and NGAL have been used successfully in the follow-up of acute kidney injury. In our study, in order to show the effect of pneumoperitoneum on acute kidney injury in patients scheduled for laparoscopic surgery, NGAL and IGF-1 values will be measured before, after and 24 hours after pneumoperitoneum, and these values will be compared.

Primary Outcome Measures

Name	Time	Method
Diagnosis of acute kidney injury in the early postoperative period with IGF-1 (insulin like growth factor-1)	before pneumoperitoneum, after pneumoperitoneum, and at the postoperative 24th hour.	The researchers investigate whether IGF-1 will be an effective indicator in acute kidney injury by comparing IGF-1 and NGAL (Neutrophil gelatinase-associated lipocalin) values before pneumoperitoneum, after pneumoperitoneum and at the postoperative 24th hour.

Trial Locations

Locations (1)

Çağla Yazar, MD; 🇹🇷 Ankara, Turkey