A New Marker for Early Diagnosis of Pneumoperitoneum-Related Acute Kidney Injury: Insulin-Like Growth Factor-1 (IGF-1)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 2
- 主要终点
- Diagnosis of acute kidney injury in the early postoperative period with IGF-1 (insulin like growth factor-1)
研究概览
简要总结
In our study, to show the effect of pneumoperitoneum on acute kidney injury in patients scheduled for laparoscopic surgery, NGAL and IGF-1 values will be measured before, after and 24 hours after pneumoperitoneum, and these values will be compared. In our study, we aimed to investigate the effect of pneumoperitoneum applied on acute kidney injury in patients who underwent laparoscopic surgery. Creatinine and NGAL have been used successfully in the follow-up of acute kidney injury. Our study investigates whether IGF-1 will be an effective indicator in acute kidney injury by comparing IGF-1 and NGAL values before pneumoperitoneum, after pneumoperitoneum and at the postoperative 24th hour.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients aged 18-70 years of both sexes
- •ASA I-III Patients
排除标准
- •Chronic Kidney Disease,
- •Chronic Renal Failure,
- •Acute Renal Failure,
- •Peripheral and ischemic vascular disease,
- •Chronic Heart Failure,
- •History of anaphylaxis,
- •A-V block,
- •Creatinine level >1.4,
- •Neuromuscular disease,
- •Malignant hypertension,
- •Pyelonephritis,
- •Urinary tract infectio,
- •Severe inflammation/possible sepsis,
- •Active malignancy,
- •Patients with surgery reversion to laparotomy,
- •Hemodynamic instability, need for vasopressors,
- •Severe bleeding requiring blood transfusion,
研究组 & 干预措施
IGF
Creatinine and NGAL have been used successfully in the follow-up of acute kidney injury. In our study, in order to show the effect of pneumoperitoneum on acute kidney injury in patients scheduled for laparoscopic surgery, NGAL and IGF-1 values will be measured before, after and 24 hours after pneumoperitoneum, and these values will be compared.
干预措施: IGF-1 (Diagnostic Test)
结局指标
主要结局
Diagnosis of acute kidney injury in the early postoperative period with IGF-1 (insulin like growth factor-1)
时间窗: before pneumoperitoneum, after pneumoperitoneum, and at the postoperative 24th hour.
The researchers investigate whether IGF-1 will be an effective indicator in acute kidney injury by comparing IGF-1 and NGAL (Neutrophil gelatinase-associated lipocalin) values before pneumoperitoneum, after pneumoperitoneum and at the postoperative 24th hour.
次要结局
未报告次要终点
研究者
Çağla Yazar, MD
Principal investigator
Baskent University