Propofol as a protective agent in postoperative attentional changes. Prospective clinical trial
- Conditions
- Adverse anesthetic effects and therapeutic gasesR41.8
- Registration Number
- RBR-6xhp399
- Lead Sponsor
- Hospital Universitário Gaffree e Guinle
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- Not specified
- Target Recruitment
- Not specified
Age above18 years; signing of the Free and Informed Consent Form about participation in the study; physical status ASA (American Society of Anesthesia) I; II and III ( one, two and three); patients undergoing general anesthesia for laparoscopic cholecystectomy and/or thyroidectomy; lasting less than 300 minutes. And control group with 60 patients not submitted to surgery.
ASA(American Society of Anesthesia) scale four; presence of neurological or psychiatric disease affecting cognition; continuous use of: corticosteroids; antipsychotics; opioids, zolpiden; tricyclic antidepressants; smoking; alcoholism; severe liver disease; renal failure (creatinine clearance under 100); inability to perform neuropsychometric tests independentes. The following perioperative situations exclude research participants: Postoperative delirium; report of anesthetic complications, including hypoxemia; hypotension and deep anesthetic plane (BIS (Bispectral Index Scale) under thirty five); report of general anesthesia up to one year prior to surgery; previous cardiac or neurological surgeries; urgent surgeries or with intraoperative surgical complications (bleeding and reoperation).
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess postoperative cognitive dysfunction (POCD) in relation to the choice of anesthetic technique in medium-sized surgeries. Through neuropsychological assessment with the Computerized Attention Test. In this test, we can measure the following variables: 1. Reaction time, 2. Reaction time variability, 3. Omission errors and 4. Commission errors. There are 4 independent variables, evaluated in the same test, where the alteration of any one of them shows attentional alteration. The analysis of the results is performed by comparing the individual's results with the standardization sample in the test manual paired by sex and age, with a difference of 1.5 standard deviation between the groups. The parameters that may be altered are:<br>Intrinsic alert; Ability to focus and sustain attention; Inhibition of inadequate responses in the postoperative period.<br><br>
- Secondary Outcome Measures
Name Time Method Aplication of other tests that prove the change in cognition related to anesthesia, such as:COWAT (Controlled oral word association test); Minimental, symbol digit modality test; MoCa (Montreal Cognition Test).<br>Comparing preoperative tests with those performed at 24h, 7 days and 30 days after surgery.<br>