Acute and delayed effects of MDMA intoxication on false memories in a legal context

Completed

Conditions: no health condition is addressed in the research, and healthy volunteers who are occasional MDMA users will be recruited
n.a.

Registration Number: NL-OMON44349

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 80

Inclusion Criteria

Healthy volunteers who have experience with the use of ecstasy/MDMA (maximally 200 times in total, minimally 3 times in total; and at least once in the past 12 months): This will be assessed by means of a drug history questionnaire and an interview by the medical supervisor
Age between 18 and 40 years
Good physical health as determined by medical examination and laboratory analysis
Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2
Written Informed Consent
Good knowledge and understanding of the English language (at least 5 years of English language education* assessed in the prescreening)

Exclusion Criteria

History of drug abuse (other than the use of MDMA) or addiction (determined by the medical questionnaire, drug questionnaire and medical examination)
Pregnancy or lactation (pregnancy test, if needed)
Use of psychotropic medication (i.e. medication prescribed by a physician)
Any major medical, endocrine and neurological condition]
Decreased liver function
Hypertension (diastolic> 90; systolic> 140)
Current or history of psychiatric disorder (determined by the medical questionnaire and medical examination)
Liver dysfunction
(Serious) side effects due to previous MDMA consumption
History of cardiac dysfunctions (arrhythmia, ischemic heart disease,*)/ cardiovascular
abnormalities as indicated by (1) The medical questionnaire and/or (2) the standard 12-lead ECG
Previous participation in study NL60303.068.16, *Acute and delayed effects of THC intoxication on false memories in a legal context*

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary: Spontaneous false memories will be measured using the<br /><br>Deese/Roediger-McDermott (DRM) paradigm. Suggestion-based<br /><br>false memories will be assessed via exposing subjects to a virtual reality mock<br /><br>crime and adding suggestive misinformation in subsequent interrogations.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary: Dissociative psychopathology (i.e., dissociative traits) will be<br /><br>measured using the Dissociative Experiences Scale (DES). Reality<br /><br>monitoring/dissociative symptoms (i.e., dissociative states) will be assessed<br /><br>using the Clinician Administered Dissociative States Scale (CADSS). Other<br /><br>parameters include constructs related to (false) memory, such as attention,<br /><br>information processing, compliance, arousal, and convergent and divergent<br /><br>thinking.</p><br>