Acute and delayed effects of THC intoxication on false memories in a legal context

Completed

Conditions: no health condition is addressed in the research, and healthy volunteers who are occasional cannabis users will be recruited
n.a.

Registration Number: NL-OMON45359

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

Occasional cannabis users (used between 1 times a month and 1 times a week during the previous year)
Aged between 18 and 40 years
Free from psychotropic medication
Good physical health as determined by medical examination and laboratory analysis
Absence of any major medical, endocrine and neurological condition
Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2
Written Informed Consent
Good knowledge and understanding of the English language (at least 5 years of English language education; assessed in the pre-screening)

Exclusion Criteria

History of drug abuse (other than the use of cannabis) or addiction (determined by the medical questionnaire, drug questionnaire and medical examination)
Pregnancy or lactation (pregnancy test, if needed)
Hypertension (diastolic> 90; systolic> 140)
Current or history of psychiatric disorder (determined by the medical questionnaire and medical examination)
Liver dysfunction
(Serious) side effects due to previous cannabis consumption
History of cardiac dysfunctions (arrhythmia, ischemic heart disease,*)

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary: Spontaneous false memories will be measured using the<br /><br>Deese/Roediger-McDermott (DRM) paradigm. Suggestion-based false memories will<br /><br>be assessed via exposing subjects to a virtual reality mock crime and adding<br /><br>suggestive misinformation in subsequent interrogations.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary: Dissociative psychopathology (i.e., dissociative traits) will be<br /><br>measured using the Dissociative Experiences Scale (DES). Reality<br /><br>monitoring/dissociative symptoms (i.e., dissociative states) will be assessed<br /><br>using the Clinician Administered Dissociative States Scale (CADSS). Other<br /><br>parameters include constructs related to (false) memory, such as attention,<br /><br>information processing, compliance, arousal, and convergent and divergent<br /><br>thinking.</p><br>