Comparing which amongst the 2 drugs Dexmedetomidine and Clonidine (alpha agonist) when added with ropivacaine (local anaesthetic) drug for epidural anaesthesia in people undergoing lower limb surgeries provides better anaesthesia and pain relief
Not Applicable
- Conditions
- Health Condition 1: M00-M99- Diseases of the musculoskeletal system and connective tissue
- Registration Number
- CTRI/2021/07/034853
- Lead Sponsor
- Dept of Anaesthesia DR S N MEDICAL COLLEGE
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patient belonging to ASA Grade 1 and 2, scheduled for Lower Limb Surgery
Exclusion Criteria
1.Pregnant and lactating women.
2.Any contraindications to epidural anaesthesia: patient refusal, uncooperative patients, hypotension, previous spinal surgeries, infection at local site, coagulation abnormalities and patients allergic to amide group of local anaesthetics.
3.Patients with uncontrolled hypertension, and cardiac diseases.
4.Patients with haematological diseases, neuromuscular diseases, severe renal or hepatic derangements.
5.Patients taking tricyclic antidepressants, alpha 2 adrenergic agonists, opioids, anti-arrythmics, beta blockers and anticoagulants.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method to compare total duration of analgesia obtained on adding dexmedetomidine and clonidine as an adjuvant to epidural anaesthesia in lower limb surgeriesTimepoint: 24 hrs
- Secondary Outcome Measures
Name Time Method To compare the Sensory blockade (onset, duration and maximum level of sensory block achieved), motor blockade ( duration and intensity), ability to provide sedation, haemodynamic parameter, intra and post operative complications if any on giving dexmedetomidine plus ropivacaine and clonidine plus ropivacaine in patients undergoing lower limb surgery under epidural anaesthesia.Timepoint: 24 hrs