The Homburg Keratoconus Center (HKC) - a Keratoconus Observation Study
Overview
- Phase
- Not Applicable
- Intervention
- Topographic, tomographic and biomechanical analysis.
- Conditions
- Keratoconus
- Sponsor
- Universität des Saarlandes
- Enrollment
- 5000
- Locations
- 2
- Primary Endpoint
- An overview about development of anterior corneal curvature in Keratoconus disease during lifetime.
- Status
- Recruiting
- Last Updated
- 5 days ago
Overview
Brief Summary
Aim of this study is to conduct longitudinal and cross-sectional analyses about the corneal ectatic disease Keratoconus based on data obtained from Keratoconus patients in the Homburg Keratoconus Center (HKC).
The Homburg Keratoconus Center (HKC) was founded in 2010 and, up to now, comprises more than 3,000 Keratoconus patients. Topographic, tomographic and biomechanic characteristics of the disease are being analyzed with the intention to elucidate how the disease begins and develops during lifetime.
Investigators
Elias Flockerzi
Principal Investigator, Resident of Ophthalmology
University Hospital, Saarland
Eligibility Criteria
Inclusion Criteria
- •All Keratoconus patients presenting in the department of ophthalmology, Saarland University Medical Center, Homburg, Saarland, Germany.
Exclusion Criteria
- •Patients without Keratoconus.
Arms & Interventions
Patients with Keratoconus
Aim is to include as many Keratoconus patients as possible with the intention to elucidate how the disease begins and develops during lifetime.
Intervention: Topographic, tomographic and biomechanical analysis.
Outcomes
Primary Outcomes
An overview about development of anterior corneal curvature in Keratoconus disease during lifetime.
Time Frame: 01/01/2011-01/01/2019
The anterior radius of curvature (ARC, 3mm zone) of Keratoconus patients as measured by the Pentacam high resolution (Oculus, Wetzlar, Germany) at different ages (according to: Belin MW and Duncan JK. Keratoconus: The ABCD grading system. Klin Monbl Augenheilkd. 2016; 233(6): 701-707) is put into relation to the age of the Keratoconus patients.
An overview about development of the best corrected distance visual acuity in Keratoconus disease during lifetime.
Time Frame: 01/01/2011-01/01/2019
The best corrected distance visual acuity of Keratoconus patients as raised as part of the clinical examination at different ages (according to: Belin MW and Duncan JK. Keratoconus: The ABCD grading system. Klin Monbl Augenheilkd. 2016; 233(6): 701-707) is put into relation to the age of the Keratoconus patients.
Reproducibility study: Kmax.
Time Frame: 01/01/2011-01/01/2019
Measurements of Kmax measured by different devices (Pentacam high resolution, Oculus, Wetzlar, Germany; Anterior-Segment Optical Coherence Tomograph (AS-OCT) Casia 2, Tomey, Nagoya, Japan) are being compared and set into relation at different Keratoconus stages with the intention to investigate, whether measurement inaccuracies occur at later Keratoconus stages using different devices.
An overview about development of the thinnest corneal pachymetry in Keratoconus disease during lifetime.
Time Frame: 01/01/2011-01/01/2019
The thinnest corneal pachymetry of Keratoconus patients as measured by the Pentacam high resolution (Oculus, Wetzlar, Germany) at different ages (according to: Belin MW and Duncan JK. Keratoconus: The ABCD grading system. Klin Monbl Augenheilkd. 2016; 233(6): 701-707) is put into relation to the age of the Keratoconus patients.
Reproducibility study: Thinnest corneal pachymetry.
Time Frame: 01/01/2011-01/01/2019
Measurements of the thinnest corneal pachymetry as measured by different devices (Pentacam high resolution, Oculus, Wetzlar, Germany; Anterior-Segment Optical Coherence Tomograph (AS-OCT) Casia 2, Tomey, Nagoya, Japan) are being compared and set into relation at different Keratoconus stages with the intention to investigate, whether measurement inaccuracies occur at later Keratoconus stages using different devices.
An overview about development of posterior corneal curvature in Keratoconus disease during lifetime.
Time Frame: 01/01/2011-01/01/2019
The posterior radius of curvature (PRC, 3mm zone) of Keratoconus patients as measured by the Pentacam high resolution (Oculus, Wetzlar, Germany) at different ages (according to: Belin MW and Duncan JK. Keratoconus: The ABCD grading system. Klin Monbl Augenheilkd. 2016; 233(6): 701-707) is put into relation to the age of the Keratoconus patients.
Reproducibility study: Thinnest corneal pachymetry at the apex position.
Time Frame: 01/01/2011-01/01/2019
Measurements of the thinnest corneal pachymetry at the apex position as measured by different devices (Pentacam high resolution, Oculus, Wetzlar, Germany; Anterior-Segment Optical Coherence Tomograph (AS-OCT) Casia 2, Tomey, Nagoya, Japan) are being compared and set into relation at different Keratoconus stages with the intention to investigate, whether measurement inaccuracies occur at later Keratoconus stages using different devices.