Biomarkers and Risk Factors for Perioperative Neurocognitive Dysfunction in Elderly Patients

Recruiting

• Conditions: Perioperative Neurocognitive Dysfunction
• Interventions: Diagnostic Test: Pittsburgh sleep quality index; Diagnostic Test: Self-rating depression scale; Diagnostic Test: Montreal Cognitive Assessment

• Registration Number: NCT06044207
• Lead Sponsor: Jinan Central Hospital

Brief Summary

Basic information and biological samples of patients were collected preoperatively and intraoperatively, and patients were divided into case and control groups by cognitive function assessment postoperatively, and risk factors and biomarkers of perioperative cognitive dysfunction were derived by analyzing and statistically processing basic information and biological samples.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-05
• Study Start: 2023-06-01
• Study First Submitted: 2023-09-12
• Study First Submitted QC: 2023-09-12
• Last Update Submitted: 2023-09-12
• Study First Posted: 2023-09-21
• Last Update Posted: 2023-09-21
• Primary Completion: 2025-06-01
• Study Completion: 2026-01-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• Age more than or equal to 65 years old
• ASA classification Ⅰ~Ⅲ grade

Exclusion Criteria

• History of previous Craniocerebral surgery or Craniocerebral trauma
• Inability to successfully complete preoperative psychological function tests
• Those who are severely deaf, speech impaired and otherwise unable to communicate.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients without perioperative neurocognitive dysfunction	Pittsburgh sleep quality index	-
Patients with perioperative neurocognitive dysfunction	Pittsburgh sleep quality index	-
Patients without perioperative neurocognitive dysfunction	Self-rating depression scale	-
Patients with perioperative neurocognitive dysfunction	Montreal Cognitive Assessment	-
Patients without perioperative neurocognitive dysfunction	Montreal Cognitive Assessment	-
Patients with perioperative neurocognitive dysfunction	Self-rating depression scale	-

Primary Outcome Measures

Name	Time	Method
Perioperative neurocognitive dysfunction	1 year postoperative	Identification of patients who develop perioperative neurocognitive disorders after surgery by postoperative follow-up with cognitive function tests

Trial Locations

Locations (1)

Jinan Central Hospital; 🇨🇳 Jinan, Shandong, China