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Investigation of endometriosis-symptoms and tumor marker CA 125 in women with Von Willebrand disease

Recruiting
Conditions
D68.00
Registration Number
DRKS00024676
Lead Sponsor
Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Recruiting
Sex
Female
Target Recruitment
104
Inclusion Criteria

female patients at least 18 years who have not reached menopause
-confirmed von Willebrand disease (every type, every severity)
-signed consent

Exclusion Criteria

-male patients
-female patients < 18 years or post-menopausal
-Von Willebrand disease not confirmed
-no signed consent

Study & Design

Study Type
observational
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Single blood sampling (5 ml): determination of tumor-marker CA 125 in serum (normally <35 U/ml)
Secondary Outcome Measures
NameTimeMethod
Survey of different gynecological parameters by patient questionnaire: <br>menstrual-complaints (first menstruation, duration, regularity, bleeding-duration/-intensity, pain), dysmenorrhea, menorrhagia, endometriosis, cervical-cancer, ovarian-cancer in first-degree-relatives, suspected endometriosis or diagnosed endometriosis, other gynecological surgeries, pregnancies (number and outcome: births, miscarriages, abortions, current pregnancy?), contraception (hormone medication?, impact on pain?), other diseases. <br><br>Additional documentation of the following data: Age, known cancer, current infections, ISTH BAT-Score (Rodeghiero et al., 2010), vWD-Type, current vWF-parameters, current treatment of vWD
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