Investigation of the prevelance of endometriosis in patients with Von-Willebrand-Disease

Recruiting

• Conditions: N80; D68.00; Endometriosis

• Registration Number: DRKS00025134
• Lead Sponsor: Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-01-21
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 150

Inclusion Criteria

female patients, 18 years or older, signed form of consent, confirmed diagnosis of endometriosis

Exclusion Criteria

male patients, age <18 years, no signed form of consent, endometriosis not confirmed

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diagnosis of Von-Willebrand-Disease based on secondary outcome (measurements and results of questionnaire)

Secondary Outcome Measures

Name	Time	Method
Single blood sample (max. 20 ml): Determination of VWF-Ag, VWF-RCo, Ratio VWF-RCo/VWF-Ag, PFA Collagen/Epinephrine, Factor VIII-Activity, Thrombin Time, Prothrombin Time, aPTT, CA125 in serum; patient survey about different hemostaseological/gynecological parameters through a questionnaire: bleeding/case history of thrombosis, bleeding-signs, surgeries (type, complications), anemia, thrombosis/embolism, infarction, family case-history regarding bleeding/thrombosis, gynecological case-history, medication; determination of ISTH BAT (Bleeding Assessment Tool) Score (Rodeghiero et al., 2010) based; additional data collection: age, initial diagnosis of endometriosis, therapy, symptoms, surgeries, method of contraception, acute/recent infections, cancerous diseases, known coagulation-disorder