Influence of scratching on skin profiles in chronic pruritus patients

Recruiting

Conditions: L28.1
L20.8
Prurigo nodularis
Other atopic dermatitis

Registration Number: DRKS00025896

Lead Sponsor: Klinik für Hautkrankheiten undKompetenzzentrum chronischer Pruritus (KCP), Universitätsklinikum Münster

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 180

Inclusion Criteria

Patients with
- Chronic pruritus patients with prurigo nodularis (with and without atopic predisposition), atopic dermatitis, (L28.1, L 20.8/L20.9) over the age of 18 years
- Skin type I – IV (Fitzpatrick classification)
- Caucasians
- Pruritus at lower arm
- Itch intensity =3, average itch, NRS 24 hours
- Presence of lichenified and non-lichenified lesional areas at the arm

Exclusion Criteria

Lack of understanding of the language
Breastfeeding / pregnant women
Disease that prevents participation in an examination
Neurological disease such as MS, epilepsy, Parkinson's, Z.n. Stroke, chronic pain syndromes such as fibromyalgia
Allergy to substances used, local anesthetics
Injuries, infections and / or tattoos in the examination area
Drug or alcohol addiction
Long-term use of opioid analgesics
Tendency to excessive scarring

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Morphological parameters: Determination of the epidermal and dermal nerve fiber density, neuronal caliber deviations, branching, characterization of nerve fibers (myelin, neuropeptides, non-peptidergic markers, expression of receptors)<br>Functional parameters: pruritus intensity evoked by electrical stimulation, pruritus / pain intensity<br>Immunohistochemical staining: expression of pruritic mediators<br>Gene expression: cutaneous global gene expression profiles, selective gene expression profiles

Secondary Outcome Measures