Influence of scratching on skin profiles in chronic pruritus patients

Conditions: L20
L29.8
Atopic dermatitis
Other pruritus

Registration Number: DRKS00014745

Lead Sponsor: Klinik für Hautkrankheiten und Kompetenzzentrum chronischer Pruritus (KCP), Universitätsklinikum Münster

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 240

Inclusion Criteria

Patients with chronic pruritus (due to atopic dermatitis, brachioradial pruritus, notalgia paresthetica or uremic pruritus); minimum age 18 years; skin type I-IV (Fitzpatrick classification); caucasians;

Exclusion Criteria

Patients who cannot complete the questionnaires due to physical or psychiatric diseases or an insufficient understanding of the German language. Patients taking antipruritic drugs. Patients with an infection at the potential biopsy area.

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Morphological parameters: epidermal and dermal nerve fiber density, caliber deviations, branching, characterization of nerve fibers (myelin, neuropeptides, non-peptidergic markers, receptor expression)<br>Functional parameters: pruritus intensity evoked by electrical stimulation, pruritus/pain intensity evoked by stimulation with cowhage<br>Immunostaining: expression of pruritic mediators<br>Gene expression: cutaneous global gene expression profiles, differential expression profiles<br>Patient questionnaires: NeuroDerm questionnaire, 5PLQ, SF12, Beck´s Depression Inventory (BDI), Trait anxiety inventory (STAI-T), Self-Administered Comorbidity Questionnaire (SCQ), Brief Pain Inventory (BPI), Pain Catastrophizing Scale, Neuropathic pain symptom inventory (NPSI).<br>Assessments will be performed once for each study pariticipant.<br>

Secondary Outcome Measures