Infusion Treatments of Chronic Peripheral Neuropathic Pain

Completed

• Conditions: Neuropathic Pain

• Registration Number: NCT06297915
• Lead Sponsor: Hacettepe University

Brief Summary

This study aimed to evaluate and compare the efficacy of ketamine and lidocaine infusion in patients with chronic peripheral neuropathic pain.

Patients who received intravenous ketamine infusion and the other patient group who received intravenous lidocaine infusion were evaluated in the study. Pain scores and quality of life were assessed with scales before treatment at two weeks, two months, and six months after treatment.

Detailed Description

This study, it was aimed to evaluate and compare the efficacy of intravenous infusion of ketamine and lidocaine, which have been known and used in pain management and which have recently increased interest in the treatment of peripheric neuropathic pain.

Study Timeline

• Study Start: 2022-05-17
• Primary Completion: 2023-05-10
• Study Completion: 2023-08-01
• Status Verified: 2024-03
• Study First Submitted: 2024-03-01
• Study First Submitted QC: 2024-03-06
• Last Update Submitted: 2024-03-06
• Study First Posted: 2024-03-07
• Last Update Posted: 2024-03-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

• 18-65 years of age
• Patients with peripheral neuropathic pain (radicular neuropathy, diabetic neuropathy, complex regional pain syndrome type 2, traumatic peripheral nerve injury, trigeminal neuralgia, postherpetic neuralgia)
• Patients who was evaluated by DN4 scores with of ≥4 points

Exclusion Criteria

• Patients with central nervous system disease .
• Patients with cancer related neuropatic pain.
• Patients with central neuropathic pain patterns.
• Patients with renal, hepatic, cardiovascular, and psychiatric diseases.
• Patients whose treatment could not be completed due to side effects or other reasons.
• Patients who had lost their follow-up .

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Neuropathic Pain Scale	Before treatment at two weeks, two months, and six months after treatment.The 7 symptoms items are scored by interviewing the patient.The scores are added and a score of 4 or more outout of ,10 point (severe pain ) is suggestive of neuropathic pain.	Neuropathic Pain 4 Questions (DN4)
Pain Rating Scale	Before treatment at two weeks, two months, and six months after treatment.NRS in which individuals rate their pain on an ten-point numerical scale. Zero:''no pain at all' ten-point ''severe pain''	Numeric Rating Scale

Secondary Outcome Measures

Name	Time	Method
Quality of Life Scale	Before treatment at two weeks, two months, and six months after treatment.12-question survey PCS and the MCS Scores above 50 indicate a better-than-average health-related quality of life, while scores below 50 suggest below-average health.	Short form-12 (SF-12)

Trial Locations

Locations (1)

Hacettepe University; 🇹🇷 Ankara, Cankaya, Turkey