effect of dexmedetomidine with different induction agents on smooth initiation of anesthesia and better cardiovascular stability during intubation.

Completed

• Conditions: ASA I &II patients posted for elective surgeries under general anesthesia

• Registration Number: CTRI/2018/02/012009

Brief Summary

There are many studies on dexmedetomidine forattenuation of stress response during laryngoscopy and intubation, but none ofthe studies evaluate the effect of dexmedetomidine with different inductionagents. This study aims to evaluate the effect of dexmedetomidine on inductionwith respect to hemodynamic response,dose  required and smoothness of induction also toevaluate the combined effect of dexmedetomidine with propofol and sevofluraneon cardiovascular response to laryngoscopy and intubation.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-02-26
• Last Update Posted: 2023-11-29

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

1.ASA I or II (no or minimal co-morbid disease) 2.Patients scheduled for elective surgeries.

Exclusion Criteria

• 1.History of allergy or contraindications study drug 2.Concomitant use of medications which may exaggerate the heart rate response of Dexmedetomidine including digoxin or β-adrenergic antagonists.
• 3.Predicted difficulty in intubation, 4.pregnant patients 5.nursing women 6.morbid obesity 7.Coronary artery disease 8.ischemic heart disease 9.heart blocks.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary objective:	1. 5min after settling in OT | 2. 2 min after administration of drug, | 3.1min after induction and | 4.at 1, 3, 5 and 10 min after intubation
1.To compare the Mean Arterial Pressure and Heart Rate response to induction with Propofol and Sevoflurane after dexmedetomidine 1ï­g/kg IV infusion.	1. 5min after settling in OT | 2. 2 min after administration of drug, | 3.1min after induction and | 4.at 1, 3, 5 and 10 min after intubation
2.To compare effectiveness of Dexmedetomidine 1ï­g/kg with propofol and Dexmedetomidine 1ï­g/kg with sevoflurane in attenuating cardiovascular response during laryngoscopy and intubation	1. 5min after settling in OT | 2. 2 min after administration of drug, | 3.1min after induction and | 4.at 1, 3, 5 and 10 min after intubation

Secondary Outcome Measures

Name	Time	Method
Secondary objective: To compare time of induction and smoothness of induction	The time of start of injection of propofol or mask placement with sevoflurane 8% was considered as ‘starting point of induction’. The patients were asked every 5 seconds, to open the eyes and loss of response to this command was defined as loss of verbal contact. Eyelash reflex will be then checked for additional confirmation of loss of consciousness which is defined as ‘induction end point’. The time taken for anesthetic induction will be recorded for both groups

Trial Locations

Locations (1)

Sri MuthuKumaran Medical College, Hospital And Research Institute; 🇮🇳 Chennai, TAMIL NADU, India

Sri MuthuKumaran Medical College, Hospital And Research Institute

🇮🇳Chennai, TAMIL NADU, India

Dr Navya C N

Principal investigator

9791793965

drcn.navya@gmail.com