From fibroblasts to stem cells to motorneurons in amyotrophic lateral sclerosis and related motor neuron diseases

Completed

• Conditions: Amyotrophic Lateral Sclerosis (ALS); motor neuron disease; 10029317

• Registration Number: NL-OMON37675
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 200

Inclusion Criteria

For healthy controls:
- Without neurological disease or a disorder similar to ALS
- Age > 18 years;For patients:
- Diagnosis of ALS or other ALS-mimic disorder
- Age > 18 years

Exclusion Criteria

For healthy controls:
- Neurological disease or a disorder similar to ALS
- Age < 18 years;For patients:
- Diagnosis unknown
- Age < 18 years

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>A better understanding of the pathogenesis of ALS is essential for the<br /><br>development of future treatment options for patients suffering from ALS. By<br /><br>creating iPS-cells from fibroblasts we will develop cell lines which will be<br /><br>used for disease modeling, with which further research can be done into the<br /><br>pathogenesis of ALS.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>nvt</p><br>