Oligodendrocyte Progenitor Cell Culture From Human Brain
Phase 1
Completed
- Conditions
- Demyelinating Diseases
- Interventions
- Procedure: Oligodendrocyte progenitor cell culture/craniotomy
- Registration Number
- NCT00283023
- Lead Sponsor
- Rajavithi Hospital
- Brief Summary
Recent developments in the understanding of stem- and progenitor cell differentiation raises hopes that brain damage in chronic neurological diseases may become repaired by systemic or focal transplantation of such cells. Clinical trials of stem- or progenitor cell transplantation in multiple sclerosis are currently premature. The researchers developed a protocol for human oligodendrocyte progenitor cell culture from human brain for the treatment of demyelinating disease.
- Detailed Description
Oligodendrocyte progenitor cell line were cultures and will be transplanted into the patient with Multiple sclerosis.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 5
Inclusion Criteria
- Male or female 20-65 years of age
- Informed consent
- Has elective craniotomy surgery
Exclusion Criteria
- HIV, hepatitis, and other central nervous system (CNS) infections
- Dementia, Alzheimer disease, and neurodegenerative disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description A Oligodendrocyte progenitor cell culture/craniotomy Progenitor cells from the patinets with Craniotomy with V-P Shunt or ventriculostomy will be collected and cultured.
- Primary Outcome Measures
Name Time Method Number of oligodendrocyte progenitor cell differentiation one month
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Assistant Professor Subsai Kongsaengdao
🇹ðŸ‡Bangkok, Thailand