Energy expenditure and sleep in response to protein/carbohydrate and fat ratio

Completed

• Conditions: obesity; severe overweight; 10000546

• Registration Number: NL-OMON37867
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Healthy, age 18-35 y, BMI 18-27 kg/m2, non-smoking, weight stable, no sleeping problems, estimated glomerular filtration rate >= 90ml/min/1.73m2

Exclusion Criteria

Smoking, use of medication, sleep problems, more than moderate alcohol consumption, estimated glomerular filtration rate < 90ml/min/1.73m2
Exclusion criteria for MRI (electronic implants, pacemakers, metal fragments in the eyes, skin or body)
For muscle protein synthesis measurement, all co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthrosis, arthritis, spasticity/rigidity, all neurological disorders and paralysis), use of anticoagulants, blood diseases, allergy for lidocain, use of gastric acid inhibitors.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary endpoints of this study are energy expenditure, substrate oxidation<br /><br>and sleep. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary endpoints of this study are body composition, fat distribution,<br /><br>muscle protein synthesis rate, expressed as fractional synthetic rate (FSR) and<br /><br>whole body protein turnover.</p><br>