octurnal protein supply during sleep as a dietary strategy to improve muscle mass in elderly

Completed

• Conditions: spieropbouw bij ouderdom; muscle loss; sarcopenia

• Registration Number: NL-OMON34886
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

Male
65-80 yr of age
no medication
BMI < 30 kg/m2

Exclusion Criteria

Comorbidities associated with muscle metabolism

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary endpoint will be muscle protein synthesis. Muscle protein synthesis<br /><br>will be calculated by differences in plasma and muscle tracer enrichments.<br /><br>Phenylalanine and tyrosine enrichment in plasma samples and in the muscle free<br /><br>amino acid pool will be measured using gas chromatography-mass spectrometry,<br /><br>while the phenylalanine enrichment in muscle proteins will be measured with<br /><br>GC-combustion IRMS. We measure muscle protein synthesis after nocturnal protein<br /><br>ingestion by nasogastric tube. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>None.</p><br>