What causes high blood pressure in young people: the heart or blood vessels?

Not Applicable

• Conditions: Paediatrics and cardiology; Circulatory System

• Registration Number: ISRCTN96138097
• Lead Sponsor: King's College London

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-08-09
• Last Update Posted: 21 August 2023
• Study Completion: 2026-09-30

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Aged 10-35 years old
2. Primary hypertension (intervention group) or BP < 90th centile (control group)
3. Able to tolerate the planned investigations
4. Not currently on anti-hypertensive medication/s or able to stop anti-hypertensive medications for 2 weeks prior to any research-related assessments.

Additional inclusion criteria control participants:
5. BMI in the normal range for age

Exclusion Criteria

1. Secondary hypertension
2. Clinical urgency to commence anti-hypertensive or unable to stop anti-antihypertensives for 2 week washout period
3. Unable to obtain adequate quality of planned cardiovascular investigations
4. Congenital heart disease
5. Cardiac dysrhythmias
6. Pregnancy or lactating mothers

Additional exclusion criteria for medication 1 (bisoprolol challenge):
7. Asthma currently treated with medication
8. Cardiac conduction abnormalities
9. Known intolerance to bisoprolol

Additional exclusion criteria for medication 2 (amlodipine challenge):
10. History of angina or myocardial infarction
11. Known intolerance to amlodipine

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Cardiac output measured MRI at baseline in hypertensive participants compared to healthy controls <br>2. Aortic ejection velocity measured using MRI at baseline in hypertensive participants compared to controls <br>

Secondary Outcome Measures

Name	Time	Method
1. Cardiac output measured using an echocardiogram before and after i) slow breathing exercise, ii) amlodipine administration and iii) bisoprolol administration <br>2. Aortic ejection velocity measured using echocardiogram before and after i) slow breathing exercise, ii) amlodipine administration and iii) bisoprolol administration <br>3. Pulse wave velocity measured using applanation tonometry before and after i) slow breathing exercise, ii) amlodipine administration and iii) bisoprolol administration <br>4. Systemic vascular resistance, heart rate, stroke volume and pulse wave velocity measured using MRI at baseline in hypertensive participants compared to controls <br>