CTRI/2023/10/058264招募中Unknown
Spleen Stiffness as a Measure to Assess the Response to ß Blocker Therapy (SPARE-B). - SPARE-B
试验速览
- 阶段
- Unknown
- 状态
- 招募中
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
入选标准
- •1.Age = 18 years
- •2.Cirrhosis of liver of different etiologies, with evidence of high-risk esophageal varices
- •3.Alcohol abstinence for 3 months
- •4.Written informed consent
排除标准
- •1.Age = 70 years
- •2.Previous or imminent variceal ligation
- •3.Non Cirrhotic Portal Hypertension
- •4.Portal vein, splenic vein thrombosis
- •5.Porto-systemic shunts > 10 mm
- •6.Patients already on beta blockers
- •7.Contraindications to beta blocker therapy :
- •a.Heart rate < 50 bpm
- •b.Systolic SBP < 100 mm Hg
- •c.Severe COPD
- •d.Atrioventricular block
- •e.Known PVD
- •f.Poor control of T2DM (HbA1c >9)
- •8.Technical difficulties for splenic stiffness measurement
- •9.Cardio-pulmonary disorders
- •10.Budd Chiari Syndrome
- •11.Grade 3 ascites
- •12.Acute Kidney Injury or Chronic Kidney Disease
- •13.Severely Obese patients (BMI > 40)
- •14.Pregnant women
- •15.Advanced HCC
- •16.Psychiatric Illness
- •17.Lack of informed consent
研究者
相似试验
招募中
不适用
Spleen Stiffness Measurement as Predictor of High-risk Esophageal Varices in Patients with Cirrhosis and Hepatocellular CarcinomaCirrhosisCirrhosisHepatocellular carcinomaEsophageal varicesPortal hypertensionEsophageal varicesPortal hypertensionHepatocellular carcinomaTCTR20240722005Khon Kaen University41
尚未招募
Unknown
Role of Splenic stiffness measurement to predict High risk esophageal varices in cirrhosisCTRI/2023/07/055222Dr Manas Kumar Panigrahi
招募中
不适用
Evaluation of spleen stiffness applicability and utility in a tertiary hospital.Liver diseasePortal hypertensionLiver cirrhosisLiver test abnormalitiesHBVHCVMALFDNL-OMON24949Foundation for Liver and Gastrointestinal Research (SLO) c/o Department of Hepatology & Gastroenterology Erasmus MC, University Medical Center Rotterdam250
Unknown
不适用
Spleen Stiffness Measurements Using Point Shear Wave Elastography Among HIV-Infected Patients1. Portal hypertension in the absence of overt parenchymal chronic liver disease has been described in small cohorts of patients with human immunodeficiency virus (HIV) with complications including variceal bleeding and ascites.2. Spleen stiffness measurements (SSM) have shown a superior association with the presence of portal hypertension compared with LSM in cirrhosis patients.HIV Infections Idiopathic Noncirrhotic Portal HypertensionTCTR20230208006Department of Internal Medicine, Phramongkutklao Hospital150
招募中
Unknown
Validation of unification of splenic hardness measurement to elucidate the pathogenesis of portal hypertensiodiffuse liver diseaseJPRN-UMIN000052852Chiba University200