Primary prevention of invasive cryptococcal disease using fluconazole prophylaxis in Human Immunodeficiency Virus (HIV) infected Ugandans
Not Applicable
Completed
- Conditions
- HIV, Acquired Immunodeficiency Syndrome (AIDS)Infections and Infestations
- Registration Number
- ISRCTN76481529
- Lead Sponsor
- Medical Research Council (MRC) (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 590
Inclusion Criteria
1. Adults (age >15)
2. CD4 count below 200 cells
3. Giving informed consent to the study
Exclusion Criteria
1. Pregnancy
2. Previous cryptococcal disease
3. Symptoms/signs suggestive of cryptococcal disease or a positive serum cryptococcal antigen test
4. Moribund or bedbound patients who are terminally ill
5. Current antiretroviral therapy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Invasive cryptococcal disease and mortality attributable to cryptococcal disease
- Secondary Outcome Measures
Name Time Method ot provided at time of registration