Prevention of transmissions by effective colonisation tracking in neonates
Recruiting
- Conditions
- prematuritybacterial colonization
- Registration Number
- DRKS00017733
- Lead Sponsor
- Institut für Infektionsprävention und Krankenhaushygiene Universitätsklinikum Freiburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
Patients, treated at the neonatal intensive care unit for at least 48 hours
Exclusion Criteria
Treatment for less than 48 hours, prior treatment at another hospital ward than the neonatal intensive care unit
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Transmission events (pathogens of the same genus/species in different patients which are indistinguishable after genotyping).<br>Patients enrolled in the study will receive a weekly microbiological screening to detect colonization by bacterial agents. Immediately after sample collection, samples are cultured and antimicrobial susceptibility testing (AST) is performed. Bacteria of the same species are genotyped by AFLP (amplified fragment-length polymorphism). Frequently occurring strains of the same species which cannot be differentiated by means of AFLP are referred to as clonal lines and further analyzed by application of whole genome sequencing (WGS).
- Secondary Outcome Measures
Name Time Method Prevalence rates of multidrug-resistant and susceptible pathogens