Risk-reduction of bacteria-transmission into the bloodstream during non-surgical periodontal therapy
Phase 4
Recruiting
- Conditions
- K05.3Chronic periodontitis
- Registration Number
- DRKS00026131
- Lead Sponsor
- Klinik für Zahnerhaltung, Parodontologie und Präventive Zahnheilkunde, Universitätsklinikum der RWTH Aachen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Minimum age 18 years, No periodontal treatment in the last two years, Generalized periodontitis up to stage 3 and grade B, Written informed consent
Exclusion Criteria
Patients who have already received periodontal treatment within the last two years, Pregnancy, Tobacco use, Dental implants, Metabolic disease with possible influence on the healing process, especially diabetes, Patients with infectious diseases, such as HIV, Hep B or Hep C, Patients undergoing chemotherapy, Patients with cystic fibrosis, Antibiosis in the last 3 months
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reduction of periodontologically significant bacteria in the pockets (detection by qPCR for various lead bacteria and additional culture for P. gingivalis), clinical attachment level
- Secondary Outcome Measures
Name Time Method Reduction of periodontologically significant bacteria in the blood, reduction of the acute phase reaction (esp. immunological parameters such as CRP, IL-6, TNF-a), periodontal recessions, probing depths, bleeding on probing (BOP), pain sensation during treatment, body temperature after treatment