Twente Lower Extremity Model safe: Improving safety and predictability of complex musculo-skeletal surgery using a patient-specific navigation system.

Completed

Conditions: None
not in this application: hip dysplasia
osteosarcoma)
this research involves healthy subjects. (at a later stage
10028377

Registration Number: NL-OMON36523

Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 10

Inclusion Criteria

Healthy, age 18-60, body mass index 17-30.

Exclusion Criteria

Deformities of the musculo-skeletal system such as scoliosis and hip dysplasia.
Use of medication that affects the functioning or the neurological control of the musculo-skeletal system.
Having had major injury or orthopedic surgery of the lower extremity at any time during life.
History of ailment related to carbohydrate metabolism, or to cardiac or muscular disease.
Being pregnant or having the intention to become pregnant during the course of the study.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Our primary outcomes are anatomical and physiological musculo-skeletal<br /><br>parameters. The anatomical parameters are extracted from MRI scans. They<br /><br>consist of muscle attachment points, muscle wrapping contours, muscle volumes,<br /><br>bony landmarks, tendon lengths and physiological cross-sectional areas of<br /><br>muscles. Physiological parameters are measured from kinematic and ground<br /><br>reaction force data, surface electromyography, oxygen measurements, and PET<br /><br>during various activities. They consist of torque around the hips, knees and<br /><br>ankle joints, joint compression forces, muscle activition timing, muscle force<br /><br>production and muscle energy consumption. The latter two are particularly<br /><br>important to validate because they are primary outcomes of the M-S models.<br /><br>Muscle energy consumption will be measured with PET.</p><br>

Secondary Outcome Measures