The Influence of Anxiety and Depression on Survival in Nasopharyngeal Carcinoma Patients: a Prospective Observational Cohort Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Nasopharyngeal Carcinoma
- Sponsor
- Sun Yat-sen University
- Enrollment
- 1000
- Locations
- 1
- Primary Endpoint
- Progress-free survival
- Last Updated
- 8 years ago
Overview
Brief Summary
This is a prospective, observational cohort study aimed to explore the influence of anxiety and depression to long term survival in nasopharyngeal carcinoma patients.
Detailed Description
Nasopharyngeal carcinoma (NPC) is endemic in Southern China and Southeast Asia. Radiotherapy (RT) and chemotherapy are the mainstays of therapy for NPC because these tumors are biologically highly radiosensitive and chemosensitive. Anxiety and depression symptoms were common psychological symptoms around the time of cancer diagnosis and were often persistent during cancer treatment. Psychological symptoms are associated with prolonged hospital stays, lower quality of life, and worse treatment adherence among patients with cancer. Depressive symptoms have been demonstrated to predict early mortality among patients with some kinds of cancer. But among NPC patients, the influence of anxiety and depression symptoms to long term survival have not be explored. Therefore, this prospective, observational cohort study aimed to explore the influence of anxiety and depression to long term survival in NPC patients.
Investigators
Hai-Qiang Mai,MD,PhD
Deputy Director of the Department of Nasopharyngeal Carcinoma
Sun Yat-sen University
Eligibility Criteria
Inclusion Criteria
- •Patients with newly histologically confirmed non-keratinizing nasopharyngeal carcinoma, including WHO II or III
- •Age between 18-70
- •Male and no pregnant female
- •Patient have signed on the informed consent, and well understood the objective and procedure of this study
Exclusion Criteria
- •The presence of uncontrolled life-threatening illness
- •Pregnancy or lactation
- •Patient with severe medical condition
Outcomes
Primary Outcomes
Progress-free survival
Time Frame: 3 years
Progress-free survival is calculated from the date of registration to the date of the first progress at any site.
Secondary Outcomes
- Locoregional Relapse-Free Survival(LRFS)(3 years)
- Anxiety related measure(Baseline, completion of radiation therapy (up to 12 weeks))
- Overall Survival(OS)(3 years)
- Distress related measure(Baseline, completion of radiation therapy (up to 12 weeks))
- Distant Metastasis-Free Survival (DMFS)(3 years)
- Complete Response (CR)(completion of radiation therapy (up to 12 weeks))
- Weight Loss(Baseline, completion of radiation therapy (up to 12 weeks))