Risk Factors Analysis of Anxiety and Depression in Patients With Herpes Zoster Neuralgia and Characteristics of Serum Biomarkers and Functional Brain Magnetic Resonance Changes
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Herpes Zoster
- Sponsor
- Huazhong University of Science and Technology
- Enrollment
- 600
- Locations
- 1
- Primary Endpoint
- HADS score
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
The goal of this observational study is to explore risk factors of anxiety and depression in patients with herpes zoster neuralgia, and the changes of certain serum biomarkers and functional brain magnetic resonance images of these patients.
Detailed Description
Patients with herpes zoster neuralgia will be recruited and take Hospital anxiety depression rating scale (Hospital anxiety and 'scale, HADS) evaluation. According to the HADS Scores, patients will be divided into depression group and no depression, or anxiety group and no anxiety group. The clinical data the of two groups will be collected and statistically analyzed to explore the risk factors of anxiety and depression, including the changes of serum biomarkers and functional brain magnetic resonance imaging in patients with herpes zoster neuralgia accompanying anxiety or depression.
Investigators
Wei Mei
Deputy director of anesthesiology
Huazhong University of Science and Technology
Eligibility Criteria
Inclusion Criteria
- •Age more than 18 years old
- •Diagnosed as herpes zoster neuralgia
- •Signing informed consent
Exclusion Criteria
- •Unable to complete the scale assessment
- •History of mental illness
Outcomes
Primary Outcomes
HADS score
Time Frame: during hospital stay, average of 1 week
Enrolled patients will be first evaluated by Hospital Anxiety and Depression Scare questionaire and according to the HADS score, patients will be divided to group with anxiety/depression and group without anxiety/depression.
Secondary Outcomes
- Interleukin (IL）-1β plasma level(during hospital stay, average of 1 week)
- C-reactive protein (CRP) plasma level(during hospital stay, average of 1 week)
- Area under curve (AUC) of topological metrics of functional brain magnetic resonance imaging(during hospital stay, average of 1 week)
- IL-2 receptor plasma level(during hospital stay, average of 1 week)
- IL-10 plasma level(during hospital stay, average of 1 week)
- Interferon(INF)-α plasma level(during hospital stay, average of 1 week)
- IL-8 plasma level(during hospital stay, average of 1 week)
- IL-6 plasma level(during hospital stay, average of 1 week)
- Brain-derived neurotrophic factor (BDNF) plasma level(during hospital stay, average of 1 week)