Evaluation of tau deposition using Florzolotau in young, healthy volunteers
- Conditions
- Not Applicable
- Registration Number
- KCT0008809
- Lead Sponsor
- Gachon University Gil Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 30
Healthy subjects aged 20 or older but younger than 40 years old.
-Pregnant women (Excluded if there is even the slightest suspicion of pregnancy based on questionnaire responses, including the last menstrual date).
-Currently breastfeeding women.
-Patients with such poor overall health that it is difficult to perform the examination.
-Individuals with conditions such as claustrophobia or other seizures.
-Patients with clear diagnoses of other causes of dementia or major neurological conditions, including traumatic brain injury, Parkinson's disease, Huntington's disease, motor neuron diseases, multiple sclerosis, etc.
-Patients diagnosed with psychiatric disorders such as schizophrenia.
-Patients with brain tumors, hydrocephalus, encephalitis, metabolic encephalopathies.
-Women who are pregnant or using intrauterine contraceptive devices.
-Individuals with cardiac pacemakers or metallic substances implanted inside the body (However, exclusion does not apply if the implanted/transplanted material is titanium or a titanium alloy or if a specialist has confirmed that there are no issues with a 3T MRI scan).
-Patients with metallic substances in the brain area, such as brain vascular clips, orthodontic devices, that can cause distortion of the MRI image.
-Individuals who have been exposed to radiation exceeding an effective dose of 50msV (5rem) in the past year.
-Individuals who have undergone PET scans, coronary angiograms, abdomen-pelvic CT scans, or similar procedures more than twice in the past year.
-Individuals working in jobs with significant radiation exposure.
-Other individuals who are deemed inappropriate for participation by the clinical investigator.
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Formation of Florzolotau SUVR average maps for healthy subjects
- Secondary Outcome Measures
Name Time Method Calculation of SUVR values in 6 regions associated with Braak stages