Adjustment of Positive End-Expiratory Pressure according to Body Mass Index during Mechanical Ventilation for Routine General AnesthesiaA Randomized Controlled Trial
Not Applicable
- Conditions
- Intraoperative VentilationPostoperative pulmonary complications
- Registration Number
- DRKS00031336
- Lead Sponsor
- niversitätsklinikum Schleswig-Holstein, Campus Kiel
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Planned surgery under general anaesthesia with endotracheal intubation. Expected duration of surgery = 2h
Written informed consent
Exclusion Criteria
- Mask anaesthesia or laryngeal mask
- Pregnant women
- Laparoscopic operations
- Thoracic surgery
- Operations with cardiopulmonary bypass
- Operations in > 10° Trendelenburg/Antitrendelenburg position
- Acute cardiac/pulmonary decompensation
- Acute respiratory distress syndrome (ARDS) according to Berlin definition
- Known pulmonary fibrosis
- Pneumonia (current or within the last 30 days)
- Chronic obstructive pulmonary disease severity GOLD IV
- BMI > 60
- Lack of capacity to consent
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Driving Pressure (?P), defined as difference between airway plateau pressure and positive end-expiratory pressure during general anesthesia
- Secondary Outcome Measures
Name Time Method Change in lung aeration score between the time points before surgery and after arrival in the recovery room (determined by lung ultrasound)<br><br>SpO2 after arrival in the recovery room (without oxygen insufflation)<br><br>Number of patients with indication for oxygen insufflation (to maintain SpO2 = 90%).<br><br>Mechanical ventilation performance (elastic-dynamic, tidal and total).<br><br>Compliance of the respiratory system<br><br>Intraoperative fluid requirements<br><br>Average intraoperative vasopressor requirements (µg/kg/min).<br><br>Number of hypotension events (MAD < 65 mmHg for > 1 min)<br><br>Time-weighted average of hypotensions <br><br>Number of intraoperative alveolar recruitment manoeuvres (to be performed only if SpO2 < 90% with FiO2 > 60%).<br><br>Postoperative pulmonary complications