Precision Medical Research of Non-immune Fetal Hydrops (NIFH)-From Prenatal Diagnosis to Intrauterine Treatment
Not Applicable
- Conditions
- Fetal Hydrops
- Interventions
- Procedure: intrauterine intervention
- Registration Number
- NCT02956564
- Lead Sponsor
- Shanghai First Maternity and Infant Hospital
- Brief Summary
Based on multi-center clinical research resources, a large-scale prospective cohort study will be conduted to make a more accurate diagnosis and intervention plan of Non-immune fetal hydrops (NIFH), and then establish NIFH accurate treatment strategy which is suitable for China's national conditions.
- Detailed Description
1. Etiological study of Non-immune fetal hydrops(NIFH):
1. Etiological study of NIFH in mid-pregnancy period;
2. Etiological study of NIFH and hygroma colli in first trimester;
3. Value assessment of technology for exome sequencing in diagnosis of NIFH;
2. The accuracy of NIFH intrauterine intervention and its effect assessment:
1. Perinatal outcomes of NIFH ;
2. The effect of intrauterine treatments.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 144
Inclusion Criteria
- Cases corresponding to diagnosis standards
- Willing to accept the regular follow-up
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Exclusion Criteria
- Immune hydrops fetalis
- Multiple pregnancy, except for twin-to-twin transfusion syndrome IV
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description exposure group intrauterine intervention subjects in this group are those who accept intrauterine intervention
- Primary Outcome Measures
Name Time Method Neonatal mortality 1 year
- Secondary Outcome Measures
Name Time Method Success rate for the operation 1 week