Precision Medical Research of Non-immune Fetal Hydrops (NIFH)-From Prenatal Diagnosis to Intrauterine Treatment
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Fetal Hydrops
- Sponsor
- Shanghai First Maternity and Infant Hospital
- Enrollment
- 144
- Primary Endpoint
- Neonatal mortality
- Last Updated
- 9 years ago
Overview
Brief Summary
Based on multi-center clinical research resources, a large-scale prospective cohort study will be conduted to make a more accurate diagnosis and intervention plan of Non-immune fetal hydrops (NIFH), and then establish NIFH accurate treatment strategy which is suitable for China's national conditions.
Detailed Description
1. Etiological study of Non-immune fetal hydrops(NIFH): 1. Etiological study of NIFH in mid-pregnancy period; 2. Etiological study of NIFH and hygroma colli in first trimester; 3. Value assessment of technology for exome sequencing in diagnosis of NIFH; 2. The accuracy of NIFH intrauterine intervention and its effect assessment: 1. Perinatal outcomes of NIFH ; 2. The effect of intrauterine treatments.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Cases corresponding to diagnosis standards
- •Willing to accept the regular follow-up
Exclusion Criteria
- •Immune hydrops fetalis
- •Multiple pregnancy, except for twin-to-twin transfusion syndrome IV
Outcomes
Primary Outcomes
Neonatal mortality
Time Frame: 1 year
Secondary Outcomes
- Success rate for the operation(1 week)