The Effect of Norepinephrine Versus Dopamine in Renal Transplant Recipients on Postoperative Graft Function

Phase 2

• Conditions: Renal Transplant
• Interventions: Drug: Dopamine; Drug: Norepinephrine

• Registration Number: NCT03107858
• Lead Sponsor: Assiut University

Brief Summary

Renal transplantation is now recognized as a treatment of choice for patients with chronic renal failure with end-stage renal disease. Renal transplantations are associated with better quality of life, better cost/benefit ratio, and possibly longer survival. Significant changes in blood pressure are common throughout the surgical procedure for kidney transplantation. All efforts are made to maintain an appropriate level of blood pressure by using an adequate intravascular volume and vasopressor administration. All efforts are made to maintain an appropriate level of blood pressure by using an adequate intravascular volume and vasopressor administration. All efforts are made to maintain an appropriate level of blood pressure by using an adequate intravascular volume and vasopressor administration. All efforts are made to maintain an appropriate level of blood pressure by using an adequate intravascular volume and vasopressor administration.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-03-24
• Study First Submitted QC: 2017-04-10
• Study First Posted: 2017-04-11
• Status Verified: 2017-10
• Last Update Submitted: 2017-10-18
• Last Update Posted: 2017-10-20
• Study Start: 2017-11-01
• Primary Completion: 2019-01-01
• Study Completion: 2019-11-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

• Patients scheduled for a living donor kidney transplantation

Exclusion Criteria

• Patients (less than 18 years old)
• Patients' refusal of consenting for enrolment in the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Dopamine	Dopamine	-
Norepinephrine	Norepinephrine	-

Primary Outcome Measures

Name	Time	Method
serum creatinine	four hours postoperatively	postoperative

Secondary Outcome Measures

Name	Time	Method
blood urea	four hours postoperatively	postoperative
renal artery diameter	four hours postoperatively	Measured postoperative through renal artery Doppler
renal artery blood flow	four hours postoperatively	Measured postoperative through renal artery Doppler
urine output	over 24 hours	postoperative

Trial Locations

Locations (1)

Assiut University Hospital; 🇪🇬 Assiut, Egypt