The Acute Effect of Exercise on Appetite Appetite-regulating Hormones and Inflammation in Children

Not Applicable

Completed

• Conditions: Obesity
• Interventions: Other: Exercise

• Registration Number: NCT02619461
• Lead Sponsor: University of Toronto

Brief Summary

This study describes the effect of acute high intensity exercise at 70% VO2peak on inflammation, stress, appetite hormones and appetite in lean and obese children and adolescents.

Detailed Description

In summary, exercise does induce a variety of metabolic mechanisms on a central and peripheral level, related to appetite other than solely gut peptides. The literature points towards a rather loose coupling when it comes to high intensity exercise and the suppression of food intake, without a clear explanation of the cause of exercise induced anorexia. This study is aimed to investigate high-intensity exercise and its effects on appetite and satiety hormones, inflammation, stress and eating behaviors on appetite and food intake.

The objective of the current study is to investigate the factors contributing to exercise-induced anorexia in lean and obese children, and maximize its translation into post-exercise suppression of food intake and promotion of negative energy balance particularly in obese children. It is hypothesized that high-intensity exercise would promote a greater suppression of food intake through suppression of appetite ratings via physiological mechanisms depending on stress and inflammation rather than gut peptides.

Study Timeline

• Study Start: 2014-08
• Study First Submitted: 2015-05-27
• Primary Completion: 2015-07
• Study Completion: 2015-10
• Status Verified: 2015-11
• Study First Submitted QC: 2015-11-29
• Last Update Submitted: 2015-11-29
• Study First Posted: 2015-12-02
• Last Update Posted: 2015-12-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 22

Inclusion Criteria

• 11 normal weight and 11 obese boys will be recruited for the study. Lean and obese boys aged 10-18 years, born full-term and with a normal body weight at birth, will be included in the study

Exclusion Criteria

• Dieters and individuals with lactose intolerance, allergies to milk and dairy products and gastrointestinal problems will be excluded from the study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Exercise	Exercise	Exercise at 70%VO2max on a recumbent bicycle for 30 minutes.

Primary Outcome Measures

Name	Time	Method
Appetite as assessed via visual analog scales	Timeperiod of 2 hours during each study intervention.	Appetite will be assessed via visual analog scales. Each item will be scored from 0-100; 0 not hungry; 100 very hungry
Biomarkers of Inflammation	4 timpoints during 2 hours during each study intervention.	Biomarkers of inflammation will be assessed such as IL-6; IL-1beta; TNF-alpha; CRP
Biomarkers of appetite	4 timpoints during 2 hours during each study intervention.	Biomarkers of appetite will be assessed such as A. Ghrelin; GLP-1; PYY and Leptin

Secondary Outcome Measures

Name	Time	Method
Biomarkers of Stress	4 timpoints during 2 hours during each study intervention.	Biomarkers of stress will be assessed such as Cortisol and Adrenalin

Trial Locations

Locations (1)

Department of Nutritional Sciences; 🇨🇦 Toronto, Ontario, Canada