Task-induced sensitized brain circuits during rTMS in major depressive disorder

Recruiting

Conditions: Major depressive disorder
10027946

Registration Number: NL-OMON51494

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 10

Inclusion Criteria

Age 18 to 65 years old;
Diagnosed with Major Depressive Disorder, current episode depressive
Indication for rTMS, as indicated by a psychiatrist
Therapy resistance defined by non-response after at least one type of
antidepressant and
one adequate psychotherapy

Exclusion Criteria

Diagnosis of bipolar disorder
Current depressive episode with psychotic traits
Acute suicidality
(History of) neurological disease;
(History of) epilepsy;
Pregnancy
Abnormal hearing or (uncorrected) vision;
Current disorder in substance abuse (opiate, ketamine, LSD, (meth)amphetamine,
cocaine,
solvents, cannabis, benzodiazepines or barbiturate) or alcohol abuse;
Any known other serious somatic health problem;
Used alcohol within the last 24 hours prior to each test session;
Used recreational drugs over a period of 72 hours prior to each test session.
rTMS contraindications: ICD, pacemaker, epilepsy in a first degree relative and
intracranial metal implants, such as a cochlear implant or deep brain
stimulator..
MRI contraindications: metal implants, claustrophobia.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Depression outcome is measured using a Hamilton Depression Rating Scale - 17<br /><br>items and the<br /><br>Inventory of Depressive Symptoms - self rated every 5 sessions.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. Changes in heart frequency using electrocardiogram (ECG) before and during<br /><br>stimulation<br /><br>2. Changes in E/I ratio using electroencephalogram (EEG) before, during and<br /><br>(directly) after stimulation.<br /><br>3. Changes in functional brain connectivity using functional MRI.</p><br>