Study of lactulose plus albumin in comparison to lactulose alone in treatment of neurocognitive changes due to chronic liver disease (hepatic encephalopathy) .
Not Applicable
- Conditions
- Health Condition 1: null- hepatic encephalopathy
- Registration Number
- CTRI/2015/01/005456
- Lead Sponsor
- G B PANT HOSPITA
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
•Cirrhosis
•Age 18-80
•Hepatic encephalopathy grade II-IV
•Informed consent
Exclusion Criteria
1.Degenerative CNS disease or major psychiatric illness
2. Serum creatinine > 1.5 mg/dl
3. Active alcohol intake <4 weeks prior to present episode
4. Others metabolic encephalopathies
5. Hepatocellular Carcinoma
6. Severe comorbidity such as CHF, Pulmonary disease, Neurological & Psychiatric problems impairing quality of life
7. Patients who are having sensitivity to albumin or contraindication of albumin
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reversal of hepatic encephalopathyTimepoint: Reversal of hepatic encephalopathy within 10 days
- Secondary Outcome Measures
Name Time Method 1. Mortality <br/ ><br>2. Hospital stay <br/ ><br>Timepoint: within 10 days