Study of Perinatal Transmission of Zidovudine-Resistant HIV Among Pregnant Women Treated With Zidovudine
- Conditions
- HIV InfectionsPregnancy
- Registration Number
- NCT00000828
- Brief Summary
To identify patterns of zidovudine ( AZT ) susceptibility among mother/infant pairs with perinatal HIV transmission.
Most HIV-infected infants acquire their disease via perinatal transmission. Since transmission of HIV-resistant strains to infants could alter the course of disease and response to currently recommended treatment, a study to assess the patterns of AZT susceptibility among mother/infant pairs with perinatal transmission is essential to delineate future therapeutic strategies.
- Detailed Description
Most HIV-infected infants acquire their disease via perinatal transmission. Since transmission of HIV-resistant strains to infants could alter the course of disease and response to currently recommended treatment, a study to assess the patterns of AZT susceptibility among mother/infant pairs with perinatal transmission is essential to delineate future therapeutic strategies.
HIV-infected pregnant women are enrolled at 20-36 weeks gestation. Patients have blood drawn for HIV culture at study entry and at delivery. Infants have blood drawn for HIV culture at delivery and at 1, 3, 6, and 18 months of age.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 250
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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Trial Locations
- Locations (29)
Los Angeles County - USC Med Ctr
🇺🇸Los Angeles, California, United States
UCLA Med Ctr / Pediatric
🇺🇸Los Angeles, California, United States
Harbor - UCLA Med Ctr / UCLA School of Medicine
🇺🇸Los Angeles, California, United States
Children's Hosp of Boston
🇺🇸Boston, Massachusetts, United States
Bellevue Hosp / New York Univ Med Ctr
🇺🇸New York, New York, United States
Univ of Miami (Pediatric)
🇺🇸Miami, Florida, United States
Brigham and Women's Hosp
🇺🇸Boston, Massachusetts, United States
San Juan City Hosp
🇵🇷San Juan, Puerto Rico
Univ of Connecticut / Farmington
🇺🇸Farmington, Connecticut, United States
Howard Univ Hosp
🇺🇸Washington, District of Columbia, United States
Connecticut Children's Med Ctr - Pediatric
🇺🇸Hartford, Connecticut, United States
Johns Hopkins Hosp - Pediatric
🇺🇸Baltimore, Maryland, United States
Children's Hosp of Washington DC
🇺🇸Washington, District of Columbia, United States
Univ of Alabama at Birmingham Schl of Med / Pediatrics
🇺🇸Birmingham, Alabama, United States
Mount Sinai Med Ctr / Pediatrics
🇺🇸New York, New York, United States
Columbia Presbyterian Med Ctr
🇺🇸New York, New York, United States
UCSD Med Ctr / Pediatrics / Clinical Sciences
🇺🇸La Jolla, California, United States
Bronx Lebanon Hosp Ctr
🇺🇸Bronx, New York, United States
Univ of Rochester Medical Center
🇺🇸Rochester, New York, United States
Baystate Med Ctr of Springfield
🇺🇸Springfield, Massachusetts, United States
Univ of Chicago Children's Hosp
🇺🇸Chicago, Illinois, United States
Long Beach Memorial (Pediatric)
🇺🇸Long Beach, California, United States
Tulane Univ / Charity Hosp of New Orleans
🇺🇸New Orleans, Louisiana, United States
Univ of Medicine & Dentistry of New Jersey / Univ Hosp
🇺🇸Newark, New Jersey, United States
Univ Hosp
🇺🇸New Orleans, Louisiana, United States
Incarnation Children's Ctr / Columbia Presbyterian Med Ctr
🇺🇸New York, New York, United States
SUNY Health Sciences Ctr at Syracuse / Pediatrics
🇺🇸Syracuse, New York, United States
Columbus Children's Hosp
🇺🇸Columbus, Ohio, United States
Duke Univ Med Ctr
🇺🇸Durham, North Carolina, United States