NSE as an Outcome Predictor of Therapeutical Hypothermia After Survived Sudden Cardiac Death
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 108
- 试验地点
- 1
- 主要终点
- neuron specific enolase (NSE) as a parameter for cerebral damage
研究概览
简要总结
Sudden cardiac death remains one of the major leading causes of death. Therapeutic hypothermia is a validated standard procedure to avoid or minimize cognitive deficits after cardiac arrest. To assess the efficiency of different cooling methods and further improve these methods, the investigators collected blood samples to measure the neuron specific enolase (NSE) in patients treated with invasive cooling as compared to patients treated with non-invasive cooling.
详细描述
Consecutive patients with restoration of spontaneous circulation after resuscitation due to sudden cardiac death were randomized to either non-invasive or invasive cooling for at least 24 hours. NSE was collected at designated time points and compared between patients treated with invasive cooling and those treated with non-invasive cooling. Neurological outcome was assessed between groups at hospital discharge and 6 months after discharge.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ROSC after sudden cardiac death (SCA) due to VF/VT or PEA/Asystolia
排除标准
- •Non-cardiac sudden death
- •Pregnancy
- •Unstable circulation with high-dose inotropics
- •Life-expectancy reducing concomitant illness
结局指标
主要结局
neuron specific enolase (NSE) as a parameter for cerebral damage
时间窗: 72 hours
Blood samples were collected at predefined time-points within 72 hours to measure neuron specific enolase.
次要结局
- time to overall survival(one year)
- neurologic outcome(6 months)