Obesity-related Genes in Taiwanese Undergoing Weight Loss

Completed

• Conditions: Morbid Obesity
• Interventions: Genetic: gender

• Registration Number: NCT01684280
• Lead Sponsor: Sung Ling Yeh

Brief Summary

To investigate:

1. Associations between miRNA and insulin signaling-related gene expressions in abdominal adipose tissues in obese subjects.

2. Differences in miRNAs expressed by intrabdominal omental adipose tissues between genders.

Detailed Description

Compared the differences in microRNA expressions of abdominal adipose tissue in morbid obese male and female subjects to elucidate the possible regulatory role of microRNA in insulin signaling-related gene expression levels and its association with biochemical markers. We hope to find a miRNA that can be used to predict the syndrome associated with obesity.

Study Timeline

• Study Start: 2010-06
• Primary Completion: 2010-09
• Study Completion: 2010-09
• Status Verified: 2012-09
• Study First Submitted: 2012-09-10
• Study First Submitted QC: 2012-09-10
• Last Update Submitted: 2012-09-11
• Study First Posted: 2012-09-12
• Last Update Posted: 2012-09-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Morbid obesity,BMIs> 40 kg/m2
• Subjects who underwent bariatric surgery

Exclusion Criteria

• Obese subjects with complicated metabolic disorders
• Thyroid disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
gender	gender	Paired samples of abdominal subcutaneous and intrabdominal omental adipose tissue were obtained from men and women who underwent bariatric surgery.

Primary Outcome Measures

Name	Time	Method
MicroRNA expression in abdominal omental adipose tissues	up to 28 weeks	MicroRNA-125a-3p expression in abdominal omental adipose tissues is associated with insulin signaling-related gene expression levels in morbid obesity

Trial Locations

Locations (1)

Taipei Medical University Hospital; 🇨🇳 Taipei, Taiwan