Biological Changes in the Adipose Tissue Among Pregnant Women With Diabetes
- Conditions
- DiabetesPregnancy
- Interventions
- Other: Diabetes
- Registration Number
- NCT02383537
- Lead Sponsor
- Hadassah Medical Organization
- Brief Summary
The aim of the research is to study the effect of miRNA, fat tissue and insulin resistance on the pathophysiology of diabetes during pregnancy. During the study fat tissue, Umbilical cord blood, placenta tissue and subcutaneous fat will be taken from pregnant diabetic woman over going a C-section. Healthy pregnant women will serve as a control group.
- Detailed Description
The aim of the research is to study the effect of miRNA, fat tissue and insulin resistance on the pathophysiology of diabetes during pregnancy. During the study:
1. fat tissue, Umbilical cord blood, placenta tissue and subcutaneous fat will be taken from pregnant diabetic woman over going a C-section.
2. Bloods will be analyzed for insulin, c-peptide, glucose and fat profile
3. Placenta and fat tissue will be analyzed for miRNA and total RNA
4. Clinical and anthropometric measurements will be taken from the mother
5. Placenta status will be taken
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 150
- age 18-45
- pregnant
- signed consent form
- going through an elective C-section
- Diabetic
- reference group: healthy women with no background illness
- <18 or >45
- chronic illness that may effect the outcome
- polypharmacy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Pregnant women with diabetes Diabetes Pregnant women with diabetes type 1, type 2 or gestational diabetes
- Primary Outcome Measures
Name Time Method miRNA profiling samles are taken during C-section samples will be analyzed after completion of collection
- Secondary Outcome Measures
Name Time Method