Identification of Novel Targets for Regulation of Adipose Tissue Mass
Not Applicable
Completed
- Conditions
- Obesity
- Interventions
- Dietary Supplement: Optifast
- Registration Number
- NCT00773565
- Lead Sponsor
- Gottfried Rudofsky
- Brief Summary
The aim of this study is to understand the metabolic changes occurring in fat tissue both during controlled weight loss that lead to the improvement of type 2 diabetes and other obesity associated metabolic disorders. The novelty of the study is the analysis of preadipocytes, a poorly characterized subfraction of the adipose tissue, which provides adipocyte precursors and thereby strongly influences adipose tissue mass changes. Knowledge of pathways involved in controlling adipose tissue composition will help to design novel intervention strategies for the treatment of obesity associated metabolic disorders such as type 2 diabetes.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 62
Inclusion Criteria
- Participants of the OPTIFAST52 program
- BMI > 30 kg/m2
Exclusion Criteria
- Rejection of informed consent by the participant
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Optifast Optifast Patients included take part at a weight reduction program over one year.
- Primary Outcome Measures
Name Time Method number of adipocytes and preadipocytes under weight loss three years
- Secondary Outcome Measures
Name Time Method metabolic function of adipocytes and preadipocytes under weight loss three years
Trial Locations
- Locations (1)
University Hospital Heidelberg
🇩🇪Heidelberg, Germany