TAC, SOD and MDA Responses to Aerobic Exercise Versus Phoenix Seed in Obese Sedentary Females

Not Applicable

Not yet recruiting

• Conditions: Aerobic Exercise Phoenix Seed, Antioxidant Potential

• Registration Number: NCT07073716
• Lead Sponsor: Cairo University

Brief Summary

the aim of this study is To assess the antioxidant potential by measuring TAC, SOD and MDA responses to aerobic exercise versus phoenix seed in 60 obese sedentary females with symptoms of systemic inflammation. • All subjects will follow the given instructions strictly during the study duration, regarding the assessment and the treatment procedure, all participants will be evaluated under the same environmental conditions

Detailed Description

reactive oxygen species (ROS) are generated as metabolic by-products by biological systems during Processes like protein phosphorylation, activation of several transcriptional factors, apoptosis, immunity, and differentiation. When ROS production increases, they start showing harmful effects on important cellular structures like proteins, lipids, and nucleic acids. A large body of evidences shows that oxidative stress can be responsible, with different degrees of importance in the onset and/or progression of several diseases as cancer, diabetes, metabolic disorders, atherosclerosis, and cardiovascular diseases.

Date seed is a waste product that is high in polyphenolics (a mjor antioxidant compounds), phenolicacid (allergic, epicatechin, catechol,chlorogenic), carotenoids, total dietary fiber (such as pectin, β-glucan, and arabinoxylan), fat, protein, minerals, and various other nutrients and functional elements Phytosterols as β-sitosterol, campesterol, and Δ5-avenasterol are The major components of date seed oil sterols (contents varied between 4.70 and 8.45 mg/g) are important micronutrients and essential structural components of the cellular membrane.they serve crucial functions, such as modulating membrane permeability and fluidity, antioxidant activity , cholesterol-lowering effects and anti-inflammatory properties in addition to their putative contribution to reducing the risk of cardiovascular diseases and affording benefits to the immune system.

Physical activity improves antioxidant defences, lowers lipid peroxidation levels and involved in the protection from cardiovascular disorders, type II diabetes, metabolic syndrome and neurodegenerative diseases like Alzheimer's disease both in adult and in aged individuals. Thus emphasizing the importance of regular physical activity to decelerate the aging-associated impairment process.

Myokines,the bioactive peptides released by skeletal muscle following exercise as acrucial regulator of metabolic and protective pathways in peripheral tissues, particularly in combating oxidative stress and inflammation through activating intracellular signalling pathways within the liver that are involved in the liver's antioxidant defences.

this study aims to compare between aerobic exercise and phoenix seed in their antioxidant potential.

Study Timeline

• Status Verified: 2025-07
• Study Start: 2025-07-10
• Study First Submitted: 2025-07-10
• Study First Submitted QC: 2025-07-10
• Last Update Submitted: 2025-07-10
• Study First Posted: 2025-07-18
• Last Update Posted: 2025-07-18
• Primary Completion: 2025-10-10
• Study Completion: 2025-11-10

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

sedentary obese female aged 35-55 years old with BMI of 30-39.9 and some symptoms of systemic inflammation (˃75 score at the inflammatory questionnaire) and had none of the exclusion criteria could be included in this study.

Exclusion Criteria

patients with orthopaedic or cardiac or any health condition that could interfere the ability to walk or exercise

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
TAC or total antioxidant capacity (blood test)	test applied before and after 2 months of the intervention protocol	TAC: Determines the total antioxidant capacity of biological samples as a valuable approach to measuring health status under oxidative stress conditions,
SOD (superoxide dismutase)	Pre- intervention and after 8 weeks of treatment	a blood test to determine the amount of SOD in blood and giving a good idea of the overall superoxide detoxifying capacity of a cell or tissue
MDA (malondialdehyde)	Pre- intervention and after 8 weeks of treatment	blood test that measures Malondialdehyde (MDA) level as a marker of oxidative stress and a contributor to all major diseases by determining the impact of oxidation in normal and cancer cells.