Central nervous effects of Exenatide i.v. vs. NaCl 0.9% on regulation of hunger and satiety in obesity and type 2 diabetes: an fMRI study. Amendment 1: increase of dosage
Phase 2
Recruiting
- Conditions
- E66Obesity
- Registration Number
- DRKS00000301
- Lead Sponsor
- niversität Leipzig
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Male
- Target Recruitment
- 20
Inclusion Criteria
BMI > 30 kg/m2
nonsmoking
right handed
German speaking
Vision (also corrected) intact
Exclusion Criteria
chronic diseases except art. hypertension and hyperlipidemia
medication except antihypertensives and lipid lowering agents
implanted metallic objects
cardiac arrhythmia
eating disorders
vegetarians/ vegans
smokers
addiction to alcohol
claustrophobia
alterations of blood count
increase of liver values
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method o defined endpoint for fMRI-trial. Analysis is performed descriptive and explorative.<br><br>It will be assessed:<br>Brain activation (BOLD-response)<br>blood samples: glucose, insulin, GLP-1, Ghrelin, exenatide<br>state of hunger (by visual analogue scale)<br>energy uptake in free buffet
- Secondary Outcome Measures
Name Time Method