A Randomized Clinical Controlled Trial To Study the Effect of Kantakari Churna in the Management of Mutrakruchra with Special Reference to Acute Cystitis.

Ayurveda is comprehensive scientific system of medicine developed though ancient wisdom, clinical experience and experimentation. Ayurvedic classical texts like Bruhattrayee and Laghutrayee have widely described Mutrakruchha. The term Mutrakruchha comes under the disorders of Mutravaha Srotas, description of this disease is mentioned in almost all classical texts which reflects its prevalence in the ancient period. It is a disease involving basti marma. As basti is one among the Trimarma, it has great therapeutic importance

Difficulty in voiding of urine is known as mutrakruchha. The Mutravaha srotas maintains haemostasis of fluids in the body, it also detoxifies the body by eliminating certain waste products through Mutra which is formed in Pakvashaygat Sthana and stored in Basti. Mutra is an outcome product of digestion of food and metabolism in the body.A healthy urinary tract is generally resistant to infections. However, for anatomical reasons female lower urinary tract is more susceptible. Predisposing factors include female sex, poor hygienic conditions, environment, poverty and illiteracy also contribute to increasing percentage of urinary tract infections. Bacteria are by far the most common invading organisms. In Mutrakruchha , the word mutra itself mean urine and kruchh that is pain and difficulty while urinating and is main complaint of patient.

A urinary tract infection (UTI) is an infection that affects part of the urinary tract.When it affects the lower urinary tract it is known as a bladder infection (cystitis). The Mutrakruchha is closely related with acute cystitis.

Infection of the bladder gives rise to symptoms of frequency, urgency, suprapubic discomfort, dysuria and cloudy offensive urine. These symptoms are often known as ‘cystitis Nowadays, due to modern lifestyle and busy schedules people more often have to depend on food which lack hygiene, nutrients and are harmful for the health. The normal urge to micturate and defecate are avoided due to fast and busy lifestyle. Suppression of these urges leads to Vegavrodh. Although, Acute Cystitis is a benign condition, recurrent episodes are associated with reduction in quality of life, a negative impact on everyday activity and working ability, disturbances in sexual life, etc. which are troublesome for patients.

The prevalence of cystitis  was found to be 30%  in india.

Kantakari churna is selected as  it is  VataKaphghna, in its Doshaghnata, it is helpful for Shaman of associated Doshas taking part in etiopathogenesis of Moortakrichhra.

Ruksha, Laghu, Tikshna properties of Kantakari choorna reduces the chances of nidus formation as well as reduces the growth of infection by inhibiting the binding property of Kaphadosha.

-    Aqueous and methanol extract of     solanum xantocarpum showed high antimicrobial activity against the E. Coli which is responsible for Urinary tract infection which plays major role in pathogenesis of Cystitis.

-    Analgesic and anti inflammatory property of Kantakari helps to reduce pain in abdomen associated with Cystitis.

-     Katu and Tiktarasa of Katakari helps in diminishing the ‘Kleda’ at Basti, ultimately preventing the growth of infection at Bastipradesh.

-    Due to Ruksha guna of Kantakari, frequency of the Urine also get decreased.

-     Thus, action of Kantakari choorna may ultimately result in reducing burning micturition, pain in abdomen associated with Cystitis due to their anti-inflammatory action.

-    Due to  SOLASODINE[15] it possess steroidal activity which reduces pain and due to  Campestrol it contains alkaloids which act on gram +ve and  gram ve bacteria.

-   Courmarin does the destruction of bacterial cell wall led to bacterial death.

Patients within Ages between 18 to 50 yrs. Both sexes were taken

Along with the patients fulfillng  criteria of  classical symptoms of mutrakruchha as mentioned in the text are selected irrespective of sex, socio-economic status, and community, written consent from patient will be taken prior to study. Computerised generated Sampling technique will be used. Total

70 number of patients will be selected and divided into two groups, named as Group A (trial group) and Group B (Control group). Kantakari Choorna Group A (trial group) with dose 2gm bd & anupana – koshna jaal and Nitrofurantoin Group B(Control group) 1tab twice day 100mg orally will be given to

patients. Both drugs will be administered in  for 5 days. Observations will be done on day 1,3,5 and 7th day.Result of study will be drawn on the basis of criteria of assessment and statistical analysis. Discussion will be done on the basis of observations and result obtained during the treatment.

Summary will be drawn and whole thesis work will be summarized. Conclusion will be drawn strictly on basis of statistical analysis and will be unbiased.