A Randomized controlled clinical trial to evaluate the efficacy between Aatarushadi Kwath Ghana Vati and Kaishore Guggul in the management of Vatarakta.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- To evaluate the efficacy of Aatarushadi Kwath Ghan Vati 500mg two times a day after meal with lukewarm water and Kaishore Guggul 500mg two times a day after meal with lukewarm water in the management of Vatarakta (Gout) with reference to increase Serum uric acid level within 45 days
研究概览
简要总结
Ayurveda is the science of life. It believes that health and wellbeing
depends on a balance between the three Doshas - Vata, Pitta, and Kapha
which are the physiologic basis of human body, when there is imbalance in
these three doshas than these causes illness.
Vatarakta is one such disease. It was first described as an independent
disease in Charak Samhita. It is a disease of Madhyam Roga Marga as it
affects mainly Sandhis.
In Ayurveda, Vatarakta is said to be caused by adhyashana, virudhasana
(which can be correlated with faulty and irregular dietary habits), krodh
(mental stress), divaswapna and prajagarana (irregular sleep habits),
misthansukhbhojinam, achankramanshila (sedentary life style) etc.
due
to these Nidanas Vata and Rakta gets vitiated. Aggravated Vata is blocked
by vitiated Rakta which in turn leads to further aggravation of Vata. This
aggravated Vata again causes vitiation of whole Rakta. these vitiated Vata
along with deranged Rakta circulates very fast all over the body due to the
Sukshma (Minuteness) and Drava (Liquid state) Guna (characters) of Vata
and Rakta respectively and undergo Dosha-Dushya Sammurchana
(Pathogenesis) in Sandhi sthana (Joints), specifically Kar, Pada and Angula
sandhi (Metacarpo and Metatarso-phalangeal joint).
The characteristics of Vatarakta resemble with those of Gout therefore it
can better be correlated with Gouty arthritis in modern medical science.
Gout is the disease of middle aged group in which an abnormality of Uric
acid metabolism that causes Hyperuricemia and deposition of Mono-
sodium urate crystal in joints causes Acute Gouty Arthritis, in soft tissue
causing tophi and tenosynovitis, in renal tubules causing urate stones and
urate nephropathy.
The general prevalence of gout is 1–4% of the general population. It occurs
in men 2–6 folds more than women. Worldwide incidence of gout
increases gradually due to poor dietary habits such as fast foods, lack of
exercises, increased incidence of obesity and metabolic syndrome.
Conventional drugs used in the management of gout like NSAIDS,
glucocorticoids, xanthine oxidase inhibitors and uricosuric drugs; have
potential side effects and a possibility of drug interaction with other
prescribed drug which restricts their use; because in modern medical
science, its management aspect still remains symptomatic with
troublesome side effects.
With these recurrence and short term benefits in modern system ofmedicine, Ayurveda can provide a very good holistic treatment option.
Today there is need to find the drug which gives long term relief without
any side effects, is easily available, no recurrence and easy to follow.
Bhaishajya Ratnawali has described the efficacy of Aatarushadi Kwath in
management of Vatarakta.
Aatarushadi kwath includes Aatarush (Vasa), Amrita (Guduchi), Erand ,
Avalguja (Bakuchi), Haritaki. Aatarush act as blood purifier.
Amrita act as
tridoshshamak , rasayan , vedna sthapan. Erand has property of
kapha-vata shamak, shoth har, used in rakta vikar. Avalguja has balya
effect on nervous system, shoth nashak and promotes rakta samvahan.
Haritaki has property of rasayan, shonit sthapan, mutral & shoth har.
These five drugs show antagonistic action on prakupit Vata doshas and
Rakta dhatu involved in Vatarakta.
In previous study Kaishore Guggul was found to be significant in the
management of Vatarakta therefore for the present study Kaishore
Guggul will be taken as a control group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Open Label
入排标准
- 年龄范围
- 20.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients having clinical signs and symptoms of Vatrakta such as Sandhi shula/Toda (Pain), Sandhi Shotha (swelling), Sparshaashatva (Tenderness), Chimichimayan (tingling sensation),team vaivarnya (Discoloration Of skin).
- •Age group having 20 to 65 years irrespective of religion, gender, socioeconomic status.
- •Patient having serum uric acid more than 7 mg/dl in male and more than 6mg/dl in female.
排除标准
- •Known case of Amavata, Sandhigata vata, SLE, Renal Disease Known case of tuberculosis of any system Chronic joint deformity Hypersensitive reaction to any drug Pregnancy Patients with chronic major illness High risk (above 65 yrs age,known cases of HTN,DM,COPD),Comorbid patients Suspected for Covid-
- •Suspected Covid-19 patients having symptoms as per ICMR guidelines.
结局指标
主要结局
To evaluate the efficacy of Aatarushadi Kwath Ghan Vati 500mg two times a day after meal with lukewarm water and Kaishore Guggul 500mg two times a day after meal with lukewarm water in the management of Vatarakta (Gout) with reference to increase Serum uric acid level within 45 days
时间窗: 45 days with follow up on 15th , 30th , 45th day
次要结局
- 1. To compare and study the efficacy of Aatarushadi Kwath Ghan Vati(2. To compare and study the efficacy of Kaishore Guggul)