Imaging Non-brain Electromagnetic Activity in Healthy Adults Using MEG

Not Applicable

Completed

• Conditions: Chronic Pain
• Interventions: Diagnostic Test: Whole-cortex MEG System (with optional EEG)

• Registration Number: NCT03232723
• Lead Sponsor: NYU Langone Health

Brief Summary

The primary purpose of this study is to determine the effectiveness of the Magnetoencephalography (MEG) instrument to record electrical activity from parts of the body other than the brain. This study will examine if electrical activity from parts of the body, other than the brain, can be imaged by the MEG instrument. Finding will contribute to studies of pain, since abnormal electrical activity in skeletal muscle is the basis of pain, which can be severe, yet there is no non-invasive way to image this abnormal activity. This is particularly relevant to deep muscle pain and back pain.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-07-25
• Study First Submitted QC: 2017-07-25
• Study First Posted: 2017-07-28
• Study Start: 2017-08-01
• Primary Completion: 2017-09-07
• Study Completion: 2017-09-07
• Status Verified: 2019-06
• Last Update Submitted: 2019-06-03
• Last Update Posted: 2019-06-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Healthy adults who are willing and able to provide informed consent.

Read More

Exclusion Criteria

• Subjects with characteristics incompatible with MEG recordings as listed on the MEG Safety checklist (Appendix A),
• Involuntary, uncontrolled tremor,
• chronic pain.
• pregnant women (based on self-report).

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
MEG Recording	Whole-cortex MEG System (with optional EEG)	Magnetic fields will be recorded using a 275-channel whole-head MEG system

Primary Outcome Measures

Name	Time	Method
Evoked activity to obtain safe and effective imaging of structures other than the brain	2 Weeks	* Hand position 1 relaxed; * Hand position 1 muscles active; * Hand position 2 relaxed; * Hand position 2 muscles active; * Neck and Jaw, relaxed; * Neck and Jaw, tensed; * Upper torso relaxed; * Area of interest 1 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.); * Area of interest 1 tensed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.); * Area of interest 2 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.); * Area of interest 2 tensed (areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.)
Determination of optimal position to obtain safe and effective imaging of structures other than the brain.	2 Weeks	* Hand position 1 relaxed; * Hand position 1 muscles active; * Hand position 2 relaxed; * Hand position 2 muscles active; * Neck and Jaw, relaxed; * Neck and Jaw, tensed; * Upper torso relaxed; * Area of interest 1 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.); * Area of interest 1 tensed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.); * Area of interest 2 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.); * Area of interest 2 tensed (areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.)

Secondary Outcome Measures

Name	Time	Method
Dominant frequency of non-brain electrical activity in healthy adults.	2 Weeks	* Hand position 1 relaxed; * Hand position 1 muscles active; * Hand position 2 relaxed; * Hand position 2 muscles active; * Neck and Jaw, relaxed; * Neck and Jaw, tensed; * Upper torso relaxed; * Area of interest 1 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.); * Area of interest 1 tensed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.); * Area of interest 2 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.); * Area of interest 2 tensed (areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.)
Location of non-brain of activity in healthy adults.	2 Weeks	* Hand position 1 relaxed; * Hand position 1 muscles active; * Hand position 2 relaxed; * Hand position 2 muscles active; * Neck and Jaw, relaxed; * Neck and Jaw, tensed; * Upper torso relaxed; * Area of interest 1 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.); * Area of interest 1 tensed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.); * Area of interest 2 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.); * Area of interest 2 tensed (areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.)

Trial Locations

Locations (1)

New York University School of Medicine; 🇺🇸 New York, New York, United States